Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/64929
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Sánchez-López, Elena | por |
dc.contributor.author | Esteruelas, Gerard | por |
dc.contributor.author | Ortiz, Alba | por |
dc.contributor.author | Espina, Marta | por |
dc.contributor.author | Prat, Josefina | por |
dc.contributor.author | Muñoz, Montserrat | por |
dc.contributor.author | Cano, Amanda | por |
dc.contributor.author | Calpena, Ana Cristina | por |
dc.contributor.author | Ettcheto, Miren | por |
dc.contributor.author | Camins, Antoni | por |
dc.contributor.author | Alsafi, Zaid | por |
dc.contributor.author | Souto, Eliana B. | por |
dc.contributor.author | García, Maria Luisa | por |
dc.contributor.author | Pujol, Montserrat | por |
dc.date.accessioned | 2020-04-19T23:35:43Z | - |
dc.date.available | 2020-04-19T23:35:43Z | - |
dc.date.issued | 2020-04-10 | - |
dc.identifier.citation | Sánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana Cristina; Ettcheto, Miren; Camins, Antoni; Alsafi, Zaid; Souto, Eliana; García, Maria Luisa; Pujol, Montserrat, Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study. Nanomaterials, 10(4), 720, 2020 | por |
dc.identifier.uri | https://hdl.handle.net/1822/64929 | - |
dc.description.abstract | Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradable polymeric PLGA nanoparticles constitute a suitable alternative to topical eye administration, as they can improve ocular bioavailability and simultaneously reduce drug induced side effects. Moreover, their prolonged drug release can enhance patient treatment adherence as they require fewer administrations. Therefore, several formulations of PLGA based nanoparticles encapsulating dexibuprofen (active enantiomer of Ibuprofen) were prepared using the solvent displacement method employing different surfactants. The formulations have been characterized and their interactions with a customized lipid corneal membrane model were studied. Ex vivo permeation through ocular tissues and in vivo anti-inflammatory efficacy have also been studied. | por |
dc.description.sponsorship | This work was supported by grant RTI2018-094120-B-I00 from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and the European Regional Development Fund. ESL wants to acknowledge the Institute of Nanoscience and Nanotechnology (ART2018 project). | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | dexibuprofen | por |
dc.subject | drug delivery system | por |
dc.subject | nanoparticles | por |
dc.subject | PLGA | por |
dc.title | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.mdpi.com/journal/nanomaterials | por |
dc.comments | CEB53636 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2020-04-11T10:25:28Z | - |
dc.identifier.eissn | 2079-4991 | por |
dc.identifier.doi | 10.3390/nano10040720 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nanomaterials | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53636_1.pdf | 5,45 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons