Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/63900
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Heleno, Sandrina A. | por |
dc.contributor.author | Ferreira, Isabel C. F. R. | por |
dc.contributor.author | Esteves, Ana Paula | por |
dc.contributor.author | Ćirić, Ana | por |
dc.contributor.author | Glamočlija, Jasmina | por |
dc.contributor.author | Martins, Anabela | por |
dc.contributor.author | Soković, Marina | por |
dc.contributor.author | Queiroz, Maria João R. P. | por |
dc.date.accessioned | 2020-02-13T09:03:18Z | - |
dc.date.available | 2020-02-13T09:03:18Z | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0278-6915 | por |
dc.identifier.uri | https://hdl.handle.net/1822/63900 | - |
dc.description.abstract | Mushroom extracts or isolated compounds may be useful in the search of new potent antimicrobial agents. Herein, it is described the synthesis of protected (acetylated) glucuronide derivatives of p-hydroxybenzoic and cinnamic acids, two compounds identified in the medicinal mushroom Ganoderma lucidum. Their antimicrobial and demelanizing activities were evaluated and compared to the parent acids and G. lucidum extract. p-Hydroxybenzoic and cinnamic acids, as also their protected glucuronide derivatives revealed high antimicrobial (antibacterial and antifungal) activity, even better than the one showed by commercial standards. Despite the variation in the order of parent acids and the protected glucuronide derivatives, their antimicrobial activity was always higher than the one revealed by the extract. Nevertheless, the extract was the only one with demelanizing activity against Aspergillus niger. The acetylated glucuronide derivatives could be deprotected to obtain glucuronide metabolites, which circulate in the human organism as products of the metabolism of the parent compounds. | por |
dc.description.sponsorship | The authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for financial support to the Portuguese NMR network and to FCT and FEDER-COMPETE/QREN/EU for the financial support through the research project PTDC/AGR-ALI/110062/2009 and the research centres (PEst-C/QUI/UI0686/2011 and PEst-OE/AGR/UI0690/2011). S.A. Heleno (BD/70304/2010) also thanks FCT, POPH-QREN and FSE. The authors also thank to Serbian Ministry of Education and Science (Grant Number 173032) for financial support. | por |
dc.language.iso | eng | por |
dc.publisher | Pergamon-Elsevier Science Ltd | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/110062/PT | por |
dc.relation | PEst-C/QUI/UI0686/2011 | por |
dc.relation | PEst-OE/AGR/UI0690/2011 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70304%2F2010/PT | por |
dc.rights | openAccess | por |
dc.subject | Acetylation | por |
dc.subject | Anti-Infective Agents | por |
dc.subject | Benzoates | por |
dc.subject | Cinnamates | por |
dc.subject | Esters | por |
dc.subject | Glucuronides | por |
dc.subject | Magnetic Resonance Spectroscopy | por |
dc.subject | Melanins | por |
dc.subject | Plant Extracts | por |
dc.subject | Reishi | por |
dc.subject | Spectrometry, Mass, Electrospray Ionization | por |
dc.subject | Ganoderma lucidum | por |
dc.subject | p-Hydroxybenzoic acid | por |
dc.subject | Cinnamic acid | por |
dc.subject | Acetylated glucuronides | por |
dc.subject | Chemical synthesis | por |
dc.subject | Antimicrobial activity | por |
dc.title | Antimicrobial and demelanizing activity of Ganoderma lucidum extract, p-hydroxybenzoic and cinnamic acids and their synthetic acetylated glucuronide methyl esters | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0278691513002688 | por |
oaire.citationStartPage | 95 | por |
oaire.citationEndPage | 100 | por |
oaire.citationVolume | 58 | por |
dc.identifier.eissn | 1873-6351 | por |
dc.identifier.doi | 10.1016/j.fct.2013.04.025 | por |
dc.identifier.pmid | 23607932 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Food and Chemical Toxicology | por |
oaire.version | AM | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Heleno et al._FCT - Revised.pdf | 320,06 kB | Adobe PDF | Ver/Abrir |