Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/63733

TítuloProliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations
Autor(es)Preto, Ana
Gonçalves, Joana
Rebocho, Ana P
Figueiredo, Joana
Meireles, Ana M
Rocha, Ana S
Vasconcelos, Helena M
Seca, Hugo
Seruca, Raquel
Soares, Paula
Sobrinho-Simões, Manuel
Palavras-chaveApoptosis
Apoptosis Regulatory Proteins
Benzenesulfonates
Cell Line, Tumor
Cell Survival
Humans
Niacinamide
Phenylurea Compounds
Phosphorylation
Proto-Oncogene Proteins B-raf
Pyridines
Sorafenib
Thyroid Neoplasms
Cell Proliferation
Mutation
Signal Transduction
Data31-Out-2009
EditoraBMC
RevistaBMC Cancer
Resumo(s)Thyroid carcinomas show a high prevalence of mutations in the oncogene BRAF which are inversely associated with RAS or RET/PTC oncogenic activation. The possibility of using inhibitors on the BRAF pathway as became an interesting therapeutic approach. In thyroid cancer cells the target molecules, implicated on the cellular effects, mediated by inhibition of BRAF are not well established. In order to fill this lack of knowledge we studied the proliferation and survival pathways and associated molecules induced by BRAF inhibition in thyroid carcinoma cell lines harbouring distinct genetic backgrounds.
TipoArtigo
URIhttps://hdl.handle.net/1822/63733
DOI10.1186/1471-2407-9-387
ISSN1471-2407
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:DBio - Artigos/Papers

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