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https://hdl.handle.net/1822/63733
Título: | Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations |
Autor(es): | Preto, Ana Gonçalves, Joana Rebocho, Ana P Figueiredo, Joana Meireles, Ana M Rocha, Ana S Vasconcelos, Helena M Seca, Hugo Seruca, Raquel Soares, Paula Sobrinho-Simões, Manuel |
Palavras-chave: | Apoptosis Apoptosis Regulatory Proteins Benzenesulfonates Cell Line, Tumor Cell Survival Humans Niacinamide Phenylurea Compounds Phosphorylation Proto-Oncogene Proteins B-raf Pyridines Sorafenib Thyroid Neoplasms Cell Proliferation Mutation Signal Transduction |
Data: | 31-Out-2009 |
Editora: | BMC |
Revista: | BMC Cancer |
Resumo(s): | Thyroid carcinomas show a high prevalence of mutations in the oncogene BRAF which are inversely associated with RAS or RET/PTC oncogenic activation. The possibility of using inhibitors on the BRAF pathway as became an interesting therapeutic approach. In thyroid cancer cells the target molecules, implicated on the cellular effects, mediated by inhibition of BRAF are not well established. In order to fill this lack of knowledge we studied the proliferation and survival pathways and associated molecules induced by BRAF inhibition in thyroid carcinoma cell lines harbouring distinct genetic backgrounds. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/63733 |
DOI: | 10.1186/1471-2407-9-387 |
ISSN: | 1471-2407 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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1471-2407-9-387.pdf | 1,37 MB | Adobe PDF | Ver/Abrir |