Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/62870
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Calejo, I. | por |
dc.contributor.author | Costa-Almeida, R. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Gomes, Manuela E. | por |
dc.date.accessioned | 2020-01-06T09:26:36Z | - |
dc.date.available | 2020-05-01T06:00:25Z | - |
dc.date.issued | 2019-04 | - |
dc.date.submitted | 2019-05 | - |
dc.identifier.citation | Calejo I., Costa-Almeida R., Reis R. L., Gomes M. E. Enthesis tissue engineering: biological requirements meet at the interface, Tissue Engineering Part B: Reviews, doi:10.1089/ten.TEB.2018.0383, 2019 | por |
dc.identifier.issn | 1937-3376 | por |
dc.identifier.uri | https://hdl.handle.net/1822/62870 | - |
dc.description.abstract | Tendon-to-bone interface (enthesis) exhibits a complex multiscale architectural and compositional organization maintained by a heterogeneous cellular environment. Orthopedic surgeons have been facing several challenges when treating tendon pullout or tear from the bony insertion due to unsatisfactory surgical outcomes and high retear rates. The limited understanding of enthesis hinders the development of new treatment options toward enhancing regeneration. Mimicking the natural tissue structure and composition is still a major challenge to be overcome. In this review, we critically assess current tendon-to-bone interface tissue engineering strategies through the use of biological, biochemical, or biophysical cues, which must be ultimately combined into sophisticated gradient systems. Cellular strategies are described, focusing on cell sources and cocultures to emulate a physiological heterotypic niche, as well as hypoxic environments, alongside with growth factor delivery and the use of platelet-rich hemoderivatives. Biomaterial design considerations are revisited, highlighting recent progresses in tendon-to-bone scaffolds. Mechanical loading is addressed to uncover prospective engineering advances. Finally, research challenges and translational aspects are considered. In summary, we highlight the importance of deeply investigating enthesis biology toward establishing foundational expertise and integrate cues from the native niche into novel biomaterial engineering, aiming at moving today's research advances into tomorrow's regenerative therapies. | por |
dc.description.sponsorship | Authors thank the support from the European Union Framework Programme for Research and Innovation HORIZON2020 [TEAMING Grant agreement No 739572 - The Discoveries CTR]; FCT–Fundação para a Ciência e a Tecnologia for the PhD grant of IC [PD/BD/128088/2016]; the Project NORTE-01-0145-FEDER-000021:“Accelerating tissue engineering and personalized medicine discoveries by the integration of key enabling nanotechnologies, marine-derived biomaterials and stem cells”, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and the ERC Consolidator grant of ME [ERC-2017-CoG-772817]. | - |
dc.language.iso | eng | por |
dc.publisher | Mary Ann Liebert | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/739572/EU | - |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F128088%2F2016/PT | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/772817/EU | - |
dc.rights | openAccess | por |
dc.subject | 2D vs 3D culture | por |
dc.subject | Cell-based strategies | por |
dc.subject | Gradient Biomaterials | por |
dc.subject | growth factors | por |
dc.subject | tendon-to-bone interface | por |
dc.subject | Tissue engineering | por |
dc.subject | 2D versus 3D culture | por |
dc.title | Enthesis tissue engineering: biological requirements meet at the interface | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.liebertpub.com/doi/abs/10.1089/ten.TEB.2018.0383 | por |
dc.comments | http://3bs.uminho.pt/node/19836 | por |
oaire.citationStartPage | 330 | por |
oaire.citationEndPage | 356 | por |
oaire.citationIssue | 4 | por |
oaire.citationVolume | 25 | por |
dc.date.updated | 2020-01-03T22:54:24Z | - |
dc.identifier.doi | 10.1089/ten.TEB.2018.0383 | por |
dc.identifier.pmid | 31038006 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Tissue Engineering Part B: Reviews | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19836-reviewTEB_Enthesis tissue engineering- biological requirements meet at the interface.pdf | 1,55 MB | Adobe PDF | Ver/Abrir |