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|Title:||Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial|
Amaral, Ronaldo J. F. C.
Oliveira, Joaquim M.
Reis, R. L.
Mesenchymal stem cells
|Journal:||Knee Surgery, Sports Traumatology, Arthroscopy|
|Citation:||Bastos R., Mathias M., Andrade R., Bastos R., Balduino A., Schott B., Amaral R. J. F. C., Oliveira J. M., Reis R. L., Rodeo S., Espregueira-Mendes J. Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial, Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA, pp. 1-11, doi:10.1007/s00167-019-05732-8, 2019|
|Abstract(s):||PURPOSE:To compare the clinical and laboratory outcomes of intra-articular injections of culture-expanded bone-derived mesenchymal stem cells (MSCs) with or without platelet-rich plasma (PRP) to intra-articular corticosteroid injections for the treatment of knee osteoarthritis (OA). METHODS:Forty-seven patients with radiographic and symptomatic knee OA were randomized into three groups for intra-articular injections: autologous bone marrow-derived culture-expanded MSCs (nâ =â 16); autologous bone marrow-derived culture-expanded MSCsâ +â PRP (nâ =â 14); and corticosteroid (nâ =â 17). The outcomes were assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) and range of motion (ROM) at baseline, 1, 2, 3, 6, 9 and 12Â months and intra-articular cytokines analysis at baseline, 6 and 12Â months postoperatively. RESULTS:The three groups showed significant improvement in most KOOS domains and global score at 1st month and all domains and global score at 12-month follow-up (pâ <â 0.05). At the 1st month, only the MSCs group showed significant differences in KOOS symptoms domain (pâ =â 0.003). The MSCs and MSCsâ +â PRP groups showed the highest percentage of improvement in most KOOS domains and global score compared to the corticosteroid group. All three groups showed a significant reduction in intra-articular levels of human interleukin-10 cytokine, from baseline to 12Â months (pâ <â 0.05). CONCLUSION:An intra-articular injection of bone marrow-derived culture-expanded MSCs with or without the addiction of PRP is effective in improving the function and decreasing symptoms caused by knee OA at 12-month follow-up. LEVEL OF EVIDENCE:II.|
|Description:||[Epub ahead of print]|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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