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TitleMyasthenia gravis: State of the art and new therapeutic strategies
Author(s)Souto, Eliana
Lima, Bernado
Campos, Joana R.
Martins-Gomes, Carlos
Souto, Selma B.
Silva, Amélia M.
KeywordsMyasthenia gravis
Acetylcholine receptors
Neuromuscular junction
Immunosuppressant drugs
Issue date15-Dec-2019
JournalJournal of Neuroimmunology
CitationSouto, Eliana; Lima, Bernado; Campos, Joana R.; Martins-Gomes, Carlos; Souto, Selma B.; Silva, Amélia M., Myasthenia gravis: State of the art and new therapeutic strategies. Journal of Neuroimmunology, 337(577080), 2019
Abstract(s)Myasthenia Gravis (MG) an autoimmune neuromuscular disease is known by the production of autoantibodies against components of the neuromuscular junction mainly to the acetylcholine receptor, which cause the destruction and compromises the synaptic transmission. This disease is characterized by fluctuating and fatigable muscle weakness, becoming more intensive with activity, but with an improvement under resting. There are many therapeutic strategies used to alleviate MG symptoms, either by improving the transmission of the nerve impulse or by ameliorating autoimmune reactions with e.g. steroids, immunosuppressant drugs, or monoclonal antibodies (rituximab and eculizumab). Many breakthroughs in the discovery of new therapeutic targets have been reported, but MG remains to be a chronic disease where the symptoms are kept in the majority of patients. In this review, we discuss the different therapeutic strategies that have been used over the years to alleviate MG symptoms, as well as innovative therapeutic approaches currently under study.
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Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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