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TitleSugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II
Author(s)Vieira, Raquel
Souto, Selma B.
Sánchez-López, Elena
López Machado, Ana
Severino, Patricia
Jose, Sajan
Santini, Antonello
Silva, Amelia M.
Fortuna, Ana
García, Maria Luisa
Souto, Eliana
Keywordsdiabetes mellitus
animal models
in vivo
administration routes
Issue date28-Aug-2019
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
JournalJournal of Clinical Medicine
CitationVieira, Raquel; Souto, Selma B.; Sánchez-López, Elena; López Machado, Ana; Severino, Patricia; Jose, Sajan; Santini, Antonello; Silva, Amelia M.; Fortuna, Ana; García, Maria Luisa; Souto, Eliana, Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndromestrategies for in vivo administration: Part-II. Journal of Clinical Medicine, 8(9), 1332, 2019
Abstract(s)Diabetes is a complex disease characterized by hyperglycemia, together with polyuria, polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic, environmental, or immune dysfunction factors leading to pancreatic ß-cell destruction depriving the organism from endogenous insulin, Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance. Depending on the type of diabetes mellitus and drug mechanism to study, the animal model should be carefully selected among the wide variety of the currently available ones. This review discusses the most common animal models currently employed to study T1DM and T2DM. Moreover, an overview on the administration routes that could be used is also discussed.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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