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https://hdl.handle.net/1822/60331
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Campo DC | Valor | Idioma |
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dc.contributor.author | Goncalves, S. Beatriz | por |
dc.contributor.author | Palha, José Marinho Cruz | por |
dc.contributor.author | Fernandes, Helena C. | por |
dc.contributor.author | Souto, Márcio R. | por |
dc.contributor.author | Pimenta, Sara | por |
dc.contributor.author | Dong, Tao | por |
dc.contributor.author | Yang, Zhaochu | por |
dc.contributor.author | Ribeiro, J. F. | por |
dc.contributor.author | Correia, J. H. | por |
dc.date.accessioned | 2019-05-16T16:42:23Z | - |
dc.date.available | 2019-05-16T16:42:23Z | - |
dc.date.issued | 2018-09-17 | - |
dc.identifier.issn | 2072-666X | - |
dc.identifier.uri | https://hdl.handle.net/1822/60331 | - |
dc.description.abstract | In optogenetic studies, the brain is exposed to high-power light sources and inadequate power density or exposure time can cause cell damage from overheating (typically temperature increasing of 2 ∘ C). In order to overcome overheating issues in optogenetics, this paper presents a neural tool capable of assessing tissue temperature over time, combined with the capability of electrical recording and optical stimulation. A silicon-based 8 mm long probe was manufactured to reach deep neural structures. The final proof-of-concept device comprises a double-sided function: on one side, an optrode with LED-based stimulation and platinum (Pt) recording points; and, on the opposite side, a Pt-based thin-film thermoresistance (RTD) for temperature assessing in the photostimulation site surroundings. Pt thin-films for tissue interface were chosen due to its biocompatibility and thermal linearity. A single-shaft probe is demonstrated for integration in a 3D probe array. A 3D probe array will reduce the distance between the thermal sensor and the heating source. Results show good recording and optical features, with average impedance magnitude of 371 k Ω , at 1 kHz, and optical power of 1.2 mW·mm −2 (at 470 nm), respectively. The manufactured RTD showed resolution of 0.2 ∘ C at 37 ∘ C (normal body temperature). Overall, the results show a device capable of meeting the requirements of a neural interface for recording/stimulating of neural activity and monitoring temperature profile of the photostimulation site surroundings, which suggests a promising tool for neuroscience research filed. | por |
dc.description.sponsorship | This work is supported by the Innovation Team for Chongqing Higher Education Construction Plan on “Smart Micro/Nano-Systems Technology and Applications” with project number CXTDX201601025. S. B. Goncalves is supported by the Portuguese Foundation for Science and Technology (FCT) under grant PD/BD/105931/2014, MIT Portugal Program. This work is also supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020—Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941 and project PTDC/CTM-REF/28406/2017 (02/SAICT/2017). ANI also supports this work through the Brain-Lighting project by FEDER funds through Portugal 2020, COMPETE 2020 with the reference POCI-01-0247-FEDER-003416. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | info:eu-repo/grantAgreement/FCT/PD/PD%2FBD%2F105931%2F2014/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147325/PT | por |
dc.relation | PTDC/CTM-REF/28406/2017 | por |
dc.rights | openAccess | por |
dc.subject | silicon neural probes | por |
dc.subject | LED chip | por |
dc.subject | thermoresistance | por |
dc.subject | temperature monitoring | por |
dc.subject | optogenetics | por |
dc.title | LED optrode with integrated temperature sensing for optogenetics | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
oaire.citationIssue | 9 | por |
oaire.citationVolume | 9 | por |
dc.date.updated | 2019-04-11T11:06:10Z | - |
dc.identifier.doi | 10.3390/mi9090473 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Micromachines | por |
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micromachines-09-00473.pdf | 6,09 MB | Adobe PDF | Ver/Abrir |