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https://hdl.handle.net/1822/59133
Título: | "Smart'' and stimulus responsive chitosan-based scaffolds/cells for bone tissue engineering: Influence of lysozyme upon scaffold degradation and osteogenic differentiation of cultured marrow stromal cells induced by cap coatings |
Autor(es): | Martins, A. M. Pham, Q. P. Malafaya, P. B. Raphael, R. M. Kasper, F. K. Reis, R. L. Mikos, A. G. |
Data: | 2008 |
Editora: | Mary Ann Liebert Inc. |
Revista: | Tissue Engineering. Part A |
Resumo(s): | [Excerpt] The present study reports the use of non-porous, ‘‘smart’’ and stimulus responsive chitosan-based scaffolds with the capability of gradual in situ pore formation for bone tissue engineering applications. Biomimetic calcium phosphate (CaP) coatings were used as a strategy to incorporate lysozyme at the surface of chitosan based materials the main objective of controlling their degradation profile as a function of immersion time. In order to confirm the concept, degradation tests with concentration similar to those incorporated into CaP chitosan-based scaffolds were used to study the degradation of the scaffolds and the formation of pores as function of immersion time. Degradation studies with lysozyme (1.5 g/L) showed the formation of pores, indicating an increase of porosity (~5% - 55% up to 21 days) resulting in porous 3-D structures with interconnected pores. […] |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/59133 |
ISSN: | 1937-3341 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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TermisEU_OP313.pdf | 32,32 kB | Adobe PDF | Ver/Abrir |