Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/59019
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Blanco-Míguez, Aitor | por |
dc.contributor.author | Fdez-Riverola, Florentino | por |
dc.contributor.author | Lourenço, Anália | por |
dc.contributor.author | Sánchez, Borja | por |
dc.date.accessioned | 2019-02-11T10:26:27Z | - |
dc.date.available | 2019-02-11T10:26:27Z | - |
dc.date.issued | 2019-05 | - |
dc.date.submitted | 2018-09 | - |
dc.identifier.citation | Blanco-Míguez, Aitor; Fdez-Riverola, Florentino; Lourenço, Anália; Sánchez, Borja, In silico prediction reveals the existence of potential bioactive neuropeptides produced by the human gut microbiota. Food Research International, 119, 221-226, 2019 | por |
dc.identifier.issn | 0963-9969 | por |
dc.identifier.uri | https://hdl.handle.net/1822/59019 | - |
dc.description.abstract | This work reports on a large-scale potential neuropeptide activity screening in human gut microbiomes deposited in public databases. In our experimental approach, the sequences of the bioactive peptides collected in the MAHMI database, mainly predicted as immunomodulatory or antitumoral, were crossed with those of the neuroactive/digestive peptides. From 91,325,790 potential bioactive peptides, only 581 returned a match when crossed against the 5949 neuroactive peptides from the NeuroPep database and the 15 digestive hormones. Relevant bacterial taxa, such as Ruminococcus sp., Clostridium sp. were found among the main producers of the matching sequences, and many of the matches corresponded to adiponectin and the hormone produced by adipocites, which is involved in glucose homeostasis. These results show, for the first time, the presence of potentially bioactive peptides produced by gut microbiota members over the nervous cells, most notably, peptides with already predicted immunomodulatory or anti-inflammatory activity. Classical (Lactobacillus sp.) and next-generation (Faecalibacterium sp.) probiotics are shown to produce these peptides, which are proposed as a potential mechanism of action of psychobiotics. Our previous experimental results showed that many of these peptides were active when incubated with immune cells, such as dendritic cells, so their effect over the nervous system innervating the gut mucosa holds significant potential and should be explored. | por |
dc.description.sponsorship | Spanish “Programa Estatal de Investigación, Desarrollo e Inovación Orientada a los Retos de la Sociedad” (Grant AGL2016-78311-R); the Asociación Española Contra el Cancer (“Obtención de péptidos bioactivos contra el Cáncer Colo-Rectal a partir de secuencias genéticas de microbiomas intestinales”, grant PS-2016). This study was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER006684). SING group thanks CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure. This work was partially supported by the Asturias Regional Plan I+D+i for research groups (FYCYT-IDI/2018/000236) and by the Consellería de Educación, Universidades e Formación Profesional (Xunta de Galicia) under the scope of the strategic funding of ED431C2018/55-GRC Competitive Reference Group | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Gut microbiota | por |
dc.subject | Bioactive peptides | por |
dc.subject | Metaproteomes | por |
dc.subject | Peptidomes | por |
dc.subject | Neuropeptides | por |
dc.subject | Anti-inflammatory | por |
dc.subject | Immunomodulatory | por |
dc.subject | Microbiome | por |
dc.title | In silico prediction reveals the existence of potential bioactive neuropeptides produced by the human gut microbiota | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S096399691930078X | por |
dc.comments | CEB50514 | por |
oaire.citationStartPage | 221 | por |
oaire.citationEndPage | 226 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 119 | por |
dc.date.updated | 2019-02-09T17:07:07Z | - |
dc.identifier.doi | 10.1016/j.foodres.2019.01.069 | por |
dc.identifier.pmid | 30884651 | por |
dc.subject.fos | Ciências Agrárias::Biotecnologia Agrária e Alimentar | por |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.subject.fos | Engenharia e Tecnologia::Biotecnologia Industrial | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Food Research International | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_50514_1.pdf | 808,38 kB | Adobe PDF | Ver/Abrir |