Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58795

TitleThe Role of Natural-Based Biomaterials in Advanced Therapies for Autoimmune Diseases
Author(s)Ferreira, H.
Fangueiro, Joana Filipa Peixoto
Neves, N. M.
KeywordsAdvanced Therapies
Autoimmune diseases
Cell therapy
Gene therapy
Natural-based biomaterials
Stem cells
Issue dateOct-2018
PublisherSpringer
JournalAdvances in Experimental Medicine and Biology
CitationFerreira H., Fangueiro J. F., Neves N. M. The Role of Natural-Based Biomaterials in Advanced Therapies for Autoimmune Diseases, Novel Biomaterials for Regenerative Medicine, Advances in Experimental Medicine and Biology, Vol. 1077, pp. 127 - 146, doi:10.1007/978-981-13-0947-2_8, 2018
Abstract(s)Autoimmune diseases (ADs) constitute a heterogeneous group of more than 100 pathophysiological conditions in which an immune response against the self is observed. The incidence and prevalence of these chronic diseases are increasing with inherently high social and economic impacts. The currently available therapies generally focus on reducing the activity of the immune system and, therefore, can present severe side effects such as enhanced patient susceptibility to opportunistic infections. Advanced therapies emerged as promising treatments and with real curative potential for ADs. Additionally, the use of natural polymers to engineer gene therapies, cell therapies and/or tissue-engineered medicinal products presents specific advantages. Natural polymers present higher affinity with biological systems than synthetic polymers, and frequently have a chemical structure and motifs similar to those existing in the extracellular matrix of the tissues. They also have good biological performance, making them very strong candidates for advanced therapy medicinal products. This review discusses the therapeutic advances and provides demonstrative examples of the role of natural-based biomaterials for the development of advanced therapies for ADs.
TypeBook part
URIhttp://hdl.handle.net/1822/58795
ISBN978-981-13-0946-5
DOI10.1007/978-981-13-0947-2_8
ISSN0065-2598
Publisher versionhttps://link.springer.com/chapter/10.1007/978-981-13-0947-2_8
Peer-Reviewedyes
AccessRestricted access (Author)
Appears in Collections:3B’s - Capítulos de Livros/Book Chapters

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