Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58766

TitleA thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release
Author(s)Chen, Y.
Gao, Y.
Silva, Lucília Pereira
Pirraco, Rogério P.
Ma, M.
Yang, L.
Reis, R. L.
Chen, J.
KeywordsHydrogel
pH-responsive
Thermo-responsive
Issue dateJul-2018
PublisherRoyal Society of Chemistry
JournalPolymer Chemistry
CitationChen Y., Gao Y., da Silva L. P., Ma M., Pirraco R. P., Yang L., Reis R. L., Chen J. A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release, Polymer Chemistry, Vol. 9, Issue 28, pp. 4063-4072, doi:10.1039/c8py00838h, 2018
Abstract(s)The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB). The thermo- or pH-sensitive triblock copolymer based on PNIPAM or PAA was synthesized by sequential RAFT polymerization and hydrolysis. By tuning the temperature or pH, the copolymer was able to form diverse nanostructures, including coreâ shell micelles, electronegative or uncharged coreâ shell structures and 3D networks with the hydrophobic forces of PNIPAM or H-bonds between PAA and PNIPAM. Furthermore, the reversible solâ gel transition of the copolymers was modulated by temperature (â ¼37 °C), pH (â ¼5) and concentration (â ¼7 wt%). The drug release potential was evaluated via in vitro injection of copolymer hydrogels into a simulated human body device. The copolymer hydrogels exhibited a sustained drug release behavior and a low instantaneous drug concentration. The MTT studies revealed that there is no noticeable cytotoxicity of NDB or NDA hydrogels against cells. Thus, the tunable drug release efficiency suggests the possibility of PNIPAM- and PAA-based environment responsive hydrogels being applied as drug carrier systems.
Typearticle
DescriptionAccepted Manuscript
URIhttp://hdl.handle.net/1822/58766
DOI10.1039/c8py00838h
ISSN1759-9962
Publisher versionhttps://pubs.rsc.org/en/content/articlelanding/2018/py/c8py00838h/unauth#!divAbstract
Peer-Reviewedyes
AccessembargoedAccess (2 Years)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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