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TitleGemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells
Author(s)Oliveira, Catarina
Neves, N. M.
Reis, R. L.
Martins, A.
Silva, T. H.
Keywordsbreast cancer cells
Drug Delivery System
endothelial cells
Polyelectrolyte complexation
Issue dateSep-2018
PublisherFuture Medicine Ltd
CitationOliveira C., Neves N. M., Reis R. L., Silva T. H., Martins A. Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells, Nanomedicine, doi:10.2217/nnm-2018-0004, 2018
Abstract(s)Aim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115â 140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35â 42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells.
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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