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|Title:||Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells|
Neves, N. M.
Reis, R. L.
Silva, T. H.
|Keywords:||breast cancer cells|
Drug Delivery System
|Publisher:||Future Medicine Ltd|
|Citation:||Oliveira C., Neves N. M., Reis R. L., Silva T. H., Martins A. Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells, Nanomedicine, doi:10.2217/nnm-2018-0004, 2018|
|Abstract(s):||Aim: To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. Materials & methods: NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Results: Final formulation resulted in stable NPs around 115â 140 nm in size and with a polydispersity index less than 0.2. Gem was encapsulated at a maximum entrapment efficiency of 35â 42%. Drug-release studies demonstrated that around 84% of Gem is released within 4 h. Cytotoxicity results of Gem-loaded NPs showed increased toxicity (around 25%) when compared with free Gem. Conclusion: The drug-loaded NPs present increased toxicity over human breast cancer cells without increasing toxic effects over endothelial cells.|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|