Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/58731

TitleMinimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles
Author(s)Brito, A.
Abul-Haija, Y. M.
Soares da Costa, D.
Novoa-Carballal, Ramon
Reis, R. L.
Ulijn, R. V.
Pires, R. A.
Pashkuleva, I.
Keywordsco-assembly
proteoglycans
self-assembly
supramolecular gels
supramolecular systems
Issue dateDec-2018
PublisherRoyal Society of Chemistry
JournalChemical Science
CitationBrito A., Abul-Haija Y. M., Soares da Costa D., Novoa-Carballal R., Reis R. L., Ulijn R. V., Pires R. A., Pashkuleva I. Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles, Chemical Science, doi: 10.1039/c8sc04361b, 2018
Abstract(s)We report the co-assembly of aromatic carbohydrate and dipeptide amphiphiles under physiological conditions as a strategy to generate minimalistic proteoglycan mimics. The resulting nanofibers present a structural, fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) core and a functional carbohydrate (Fmoc-glucosamine-6-sulfate or -phosphate) shell. The size, degree of bundling and mechanical properties of the assembled structures depend on the chemical nature of the carbohydrate amphiphile used. In cell culture medium, these nanofibers can further organize into supramolecular hydrogels. We demonstrate that, similar to proteoglycans, the assembled gels prolong the stability of growth factors and preserve the viability of cultured cells. Our results demonstrate that this approach can be applied to the design of extracellular matrix (ECM) substitutes for future regenerative therapies.
TypeArticle
URIhttp://hdl.handle.net/1822/58731
DOI10.1039/c8sc04361b
ISSN2041-6520
Publisher versionhttps://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc04361b
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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