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|Title:||Commercial products for osteochondral tissue repair and regeneration|
|Author(s):||Bicho, Diana Stefania Faria|
Pina, Sandra Cristina Almeida
Reis, R. L.
Oliveira, J. M.
Bone, cartilage, and osteochondral regeneration
|Journal:||Advances in Experimental Medicine and Biology|
|Citation:||Bicho D., Pina S., Reis R. L., Oliveira J. M. Commercial Products for Osteochondral Tissue Repair and Regeneration., Osteochondral Tissue Engineering. Advances in Experimental Medicine and Biology, Vol. 1058, doi:10.1007/978-3-319-76711-6_19, 2018|
|Abstract(s):||The osteochondral tissue represents a complex structure composed of four interconnected structures, namely hyaline cartilage, a thin layer of calcified cartilage, subchondral bone, and cancellous bone. Due to the several difficulties associated with its repair and regeneration, researchers have developed several studies aiming to restore the native tissue, some of which had led to tissue-engineered commercial products. In this sense, this chapter discusses the good manufacturing practices, regulatory medical conditions and challenges on clinical translations that should be fulfilled regarding the safety and efficacy of the new commercialized products. Furthermore, we review the current osteochondral products that are currently being marketed and applied in the clinical setting, emphasizing the advantages and difficulties of each one.|
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