Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/56293

TitleBiological performance of a promising Kefiran-biopolymer with potential in regenerative medicine applications: a comparative study with hyaluronic acid
Author(s)Radhouani, H.
Gonçalves, C.
Maia, F. R.
Oliveira, J. M.
Reis, R. L.
KeywordsAnti-inflammatory activity
Antioxidant activity
Human adipose-derived stem cells
Kefiran polysaccharide
regenerative medicine.
Issue dateJul-2018
PublisherSpringer
JournalJournal of Materials Science: Materials in Medicine
CitationRadhouani H., Gonçalves C., Maia F. R., Oliveira J. M., Reis R. L. Biological performance of a promising Kefiran-biopolymer with potential in regenerative medicine applications: a comparative study with hyaluronic acid, Journal of Materials Science: Materials in Medicine, Vol. 29, pp. 124-134, doi:10.1007/s10856-018-6132-7, 2018
Abstract(s)Kefiran from kefir grains, an exopolysaccharide (EPS) produced by lactic acid bacteria (LAB), has received an increasing interest because of its safe status. This natural biopolymer is a water-soluble glucogalactan with probed health-promoting properties. However, its biological performance has yet to be completely recognized and properly exploited. This research was carried out to evaluate the in vitro antioxidant and the in vitro anti-inflammatory properties of Kefiran biopolymer. Regarding antioxidant activity, the results demonstrated that the Kefiran extract possessed the strongest reducing power and superoxide radical scavenging, over hyaluronic acid (HA, gold standard viscosupplementation treatment). This exopolysaccharide showed a distinct antioxidant performance in the majority of in vitro working mechanisms of antioxidant activity comparing to HA. Moreover, Kefiran presented an interesting capacity to scavenge nitric oxide radical comparing to the gold standard that did not present any potency. Finally, the cytotoxic effects of Kefiran extracts on hASCs were also performed and demonstrated no cytotoxic response, ability to improve cellular function of hASCs. This study demonstrated that Kefiran represented a great scavenger for reactive oxygen and nitrogen species and showed also that it could be an excellent candidate to promote tissue repair and regeneration.
TypeArticle
URIhttp://hdl.handle.net/1822/56293
DOI10.1007/s10856-018-6132-7
ISSN0957-4530
Publisher versionhttps://link.springer.com/article/10.1007%2Fs10856-018-6132-7
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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