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https://hdl.handle.net/1822/55253
Título: | Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition |
Autor(es): | Rodrigues, Célia Fortuna Rodrigues, M. Elisa. Henriques, Mariana |
Palavras-chave: | Candida glabrata echinocandin biofilm matrix antifungal drug resistance |
Data: | 2018 |
Editora: | Taylor and Francis |
Revista: | Biofouling: The Journal of Bioadhesion and Biofilm Research |
Citação: | Rodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition. Biofouling - The Journal of Bioadhesion and Biofilm Research, 34(5), 569-578, 2018 |
Resumo(s): | Candidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing. The goal of this work was to determine the susceptibility of C. glabrata biofilms to echinocandins and to evaluate their effect on the biofilm matrix composition, comparing the results with other Candida species. Drug susceptibilities were assessed through the determination of minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum biofilm eradication concentration (MBEC) of caspofungin (Csf) and micafugin (Mcf). The -1,3 glucans content of the matrices was assessed after contact with the drugs. The data suggest that, generally, after contact with echinocandins, the concentration of -1,3 glucans increased. These adjustments in the matrix composition of C. glabrata biofilms and the chemical differences between Csf and Mcf, seem responsible and may determine the effectivity of the drug responses. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/55253 |
DOI: | 10.1080/08927014.2018.1472244 |
ISSN: | 0892-7014 |
e-ISSN: | 1029-2454 |
Versão da editora: | http://www.tandfonline.com/action/journalInformation?journalCode=gbif20 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47720_1.pdf | 1,23 MB | Adobe PDF | Ver/Abrir |