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TitleSusceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition
Author(s)Rodrigues, Célia Fortuna
Rodrigues, M. Elisa.
Henriques, Mariana
KeywordsCandida glabrata
antifungal drug
Issue date2018
PublisherTaylor and Francis
JournalBiofouling: The Journal of Bioadhesion and Biofilm Research
CitationRodrigues, Célia F.; Rodrigues, M. Elisa; Henriques, Mariana, Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition. Biofouling - The Journal of Bioadhesion and Biofilm Research, 34(5), 569-578, 2018
Abstract(s)Candidiases are the most recurrent fungal infections, especially among immunosuppressed patients. Although Candida albicans is still the most widespread isolated species, non-Candida albicans Candida species have been increasing. The goal of this work was to determine the susceptibility of C. glabrata biofilms to echinocandins and to evaluate their effect on the biofilm matrix composition, comparing the results with other Candida species. Drug susceptibilities were assessed through the determination of minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum biofilm eradication concentration (MBEC) of caspofungin (Csf) and micafugin (Mcf). The -1,3 glucans content of the matrices was assessed after contact with the drugs. The data suggest that, generally, after contact with echinocandins, the concentration of -1,3 glucans increased. These adjustments in the matrix composition of C. glabrata biofilms and the chemical differences between Csf and Mcf, seem responsible and may determine the effectivity of the drug responses.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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