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TitleCell-based approaches for tendon regeneration
Author(s)Gonçalves, A. I.
Costa-Almeida, R.
Gershovich, P.
Rodrigues, M. T.
Reis, R. L.
Gomes, Manuela E.
KeywordsCell therapies
Extracellular matrix
Stem cells
Tendon Tissue Engineering
Tenogenic differentiation
Issue dateAug-2015
CitationGonçalves A. I., Costa-Almeida R., Gershovich P., Rodrigues M. T., Reis R. L., Gomes M. E. Cell-Based Approaches for Tendon Regeneration, Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes, pp. 187–203, doi:10.1016/B978-0-12-801590-2.00006-5, 2015
Abstract(s)Cell based therapies have been proposed as potential alternative solutions towards efficient regenerative strategies for damaged tendon tissues. These approaches traditionally envision the delivery of cells, mostly stem cells or tendon cells, often combined with carriers and growth factors to provide the behavioral instructions similar to the ones found in native tissues. The purpose of cell based therapies is to apply living cells to guide and promote enhanced tissue repair and functional regeneration of an injured or diseased tissue. This chapter will focus on the potential of several cell sources, including stem cells from different origins, in tendon regeneration, illustrated by their therapeutic role in animal models of tendinopathies. Furthermore, it will be also addressed experimental cellular therapies currently ongoing in clinical trials that hold the promise for innovative clinical outcomes in tendon regeneration.
TypeBook part
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Capítulos de Livros/Book Chapters

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