Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/54419
Título: | Construction of a biocompatible and antioxidant multilayer coating by layer-by-layer assembly of -carrageenan and quercetin nanoparticles |
Autor(es): | Souza, M. Vaz, Antônio F. M. Costa, Thacianna B. Cerqueira, Miguel Ângelo Parente Ribeiro De Castro, Célia M. M. B. Vicente, A. A. Carneiro-da-Cunha, Maria G. |
Palavras-chave: | Biomaterial Cytotoxicity Multilayer Polyelectrolyte Surface modification |
Data: | Mai-2018 |
Editora: | Springer Nature |
Revista: | Food and Bioprocess Technology |
Citação: | Souza, M.; Vaz, Antônio F. M.; Costa, Thacianna B.; Cerqueira, Miguel A.; De Castro, Célia M. M. B.; Vicente, António A.; Carneiro-da-Cunha, Maria G., Construction of a biocompatible and antioxidant multilayer coating by layer-by-layer assembly of -carrageenan and quercetin nanoparticles. Food and Bioprocess Technology, 11(5), 1050-1060, 2018 |
Resumo(s): | The present work aimed at the construction and characterization of a multilayer coating based on -carrageenan and quercetin-loaded lecithin/chitosan nanoparticles (Np) by the layer-by-layer technique and the evaluation of its antioxidant capacity and potential cytotoxicity in vitro. The multilayered coating was successfully self-assembled, as confirmed by UV-Vis spectroscopy, contact angle, atomic force microscopy (AFM), and scanning electron microscopy (SEM). Multilayered coatings showed to have antioxidant capacity, with a DPPH radical scavenging activity of 31.32±3.13% and a result of the FRAP assay of 799.41±95.39 M of ferrous ion (Fe2+) equivalent. These coatings were also shown to be devoid of cell toxicity, as evaluated by determination of nitric oxide production and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test. The alveolar macrophages culture was tested in the presence of the -carrageenan/quercetin-Np multilayer coating and showed a cell viability of 91.3±9.6%. These results suggest that this multilayered coating is adequate for surfaces modification in view of biomedical and food industry applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/54419 |
DOI: | 10.1007/s11947-018-2077-6 |
ISSN: | 1935-5130 |
e-ISSN: | 1935-5149 |
Versão da editora: | http://www.springer.com/food+science/journal/11947 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47456_1.pdf | 3,17 MB | Adobe PDF | Ver/Abrir |