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https://hdl.handle.net/1822/53776
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Campo DC | Valor | Idioma |
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dc.contributor.author | Freitas, Ana Isabel | por |
dc.contributor.author | Lopes, N. | por |
dc.contributor.author | Oliveira, Fernando E. | por |
dc.contributor.author | Brás, Susana | por |
dc.contributor.author | França, Angela | por |
dc.contributor.author | Vasconcelos, C. | por |
dc.contributor.author | Vilanova, Manuel | por |
dc.contributor.author | Cerca, Nuno | por |
dc.date.accessioned | 2018-03-29T18:05:00Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | Freitas, Ana Isabel; Lopes, N.; Oliveira, Fernando E.; Brás, Susana; França, Angela; Vasconcelos, C.; Vilanova, Manuel; Cerca, Nuno, Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates. Future Microbiology, 13(4), 415-427, 2018 | por |
dc.identifier.issn | 1746-0913 | por |
dc.identifier.uri | https://hdl.handle.net/1822/53776 | - |
dc.description.abstract | Aim: To understand the relationship between ica, aap and bhp gene expression and the implications in biofilm formation in selected clinical and commensal Staphylococcus epidermidis isolates. Material & methods: Isolates were analyzed regarding their biofilm-forming capacity, biochemical matrix composition, biofilm spatial organization and expression of biofilm-related genes. Results: On polysaccharide intercellular adhesin-dependent biofilms, aap and bhp contributions for the biofilm growth were negligible, despite very high levels of expression. In contrast, smaller increases in icaA expression contributed significantly to biofilm growth. Interestingly, no biological differences were observed between clinical and commensal strains. Conclusion: These results reinforce the concept that S. epidermidis is an 'accidental pathogen,' and that the ica operon is the main mechanism of biofilm formation in clinical and commensal isolates. © 2018 Future Medicine Ltd. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 and by COMPETE grants PTDC/BIA-MIC/113450/2009 (FCOMP-01-0124-FEDER-014309). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | por |
dc.language.iso | eng | por |
dc.publisher | Future Medicine Ltd | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113450/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | biofilm development | por |
dc.subject | commensal and clinical S. epidermidis | por |
dc.subject | gene expression quantification | por |
dc.subject | matrix composition and biofilm organization | por |
dc.title | Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.futuremedicine.com/loi/fmb | por |
dc.comments | CEB47496 | por |
oaire.citationStartPage | 415 | por |
oaire.citationEndPage | 427 | por |
oaire.citationIssue | 4 | por |
oaire.citationConferencePlace | United Kingdom | - |
oaire.citationVolume | 13 | por |
dc.date.updated | 2018-03-24T23:06:32Z | - |
dc.identifier.eissn | 1746-0921 | por |
dc.identifier.doi | 10.2217/fmb-2017-0140 | por |
dc.identifier.pmid | 29469610 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Future Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
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document_47496_1.pdf Acesso restrito! | 10,21 MB | Adobe PDF | Ver/Abrir |