Exploiting the antiparasitic activity of naphthalimides derivatives

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/51995

Registo completo

Campo DC	Valor	Idioma
dc.contributor.author	Silva, Anabela Cordeiro da	por
dc.contributor.author	Alves, Maria José Chão	por
dc.contributor.author	Thoo-Lin, Paul Kong	por
dc.contributor.author	Baptista, Catarina	por
dc.contributor.author	Noro, Jennifer Martins	por
dc.contributor.author	Cristo, Gabriela	por
dc.contributor.author	Gaspar, Luís	por
dc.date.accessioned	2018-03-09T17:17:55Z	-
dc.date.available	2018-03-09T17:17:55Z	-
dc.date.issued	2016	-
dc.identifier.issn	2321-3132	por
dc.identifier.uri	https://hdl.handle.net/1822/51995	-
dc.description.abstract	A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmaniainfantum, Trypanosomabrucei and Trypanosomacruzi. Additionally, toxicity was determined by growth inhibition of THP-1 derived macrophages. The results suggest that chemical modifications in the carbon chain linking the naphthalimide and the substituting groups have different effects in the parasites. This work should provide new insights new insights for the design and optimization of more potent and directed naphthalimide derivatives against these organisms.	por
dc.description.sponsorship	The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreements No.602773 (Project KINDRED). L.G. was supported by the Fundaçãopara a Ciência e Tecnologia through grant SFRH/BD/81604/2011.The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreements No.602773 (Project KINDRED). Thanks are due also to the NMR Portuguese network (PTNMR, BrukerAvance III 400Univ. Minho), and FCT and FEDER for financial support to CQ/UM.	por
dc.language.iso	eng	por
dc.publisher	Pharma Research Library	por
dc.relation	info:eu-repo/grantAgreement/EC/FP7/602773/EU	por
dc.relation	info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81604%2F2011/PT	por
dc.rights	openAccess	por
dc.subject	Naphtalimides derivatives	por
dc.subject	anti-parasitic activity	por
dc.subject	cytotoxicity	por
dc.title	Exploiting the antiparasitic activity of naphthalimides derivatives	por
dc.type	article	por
dc.peerreviewed	yes	por
oaire.citationStartPage	19	por
oaire.citationEndPage	23	por
oaire.citationVolume	4	por
dc.subject.fos	Ciências Naturais::Ciências Químicas	por
dc.description.publicationversion	info:eu-repo/semantics/publishedVersion	por
sdum.journal	International Journal of Chemistry and Pharmaceutical Sciences	por
Aparece nas coleções:	CDQuim - Artigos (Papers)

Ficheiros deste registo:

Ficheiro	Descrição	Tamanho	Formato
Gallery Proof IJCPS2793.pdf		292,77 kB	Adobe PDF	Ver/Abrir

Ver registo simples Sugerir correção Estatísticas