Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51753

TitleThe absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells
Author(s)Loureiro, Ana Isabel Sá
Jennifer Noro
Abreu, Ana S.
Nogueira, E.
Soares da Costa, Diana
Silva, Carla
Cavaco-Paulo, Artur
Keywordsfolic acid-Poloxamer 407 conjugate
folic acid-Poloxamer 407 nanoparticles
nanoparticle disruption
specific drug release
cancer therapy
Issue dateFeb-2018
PublisherAmerican Chemical Society
JournalMolecular Pharmaceutics
CitationLoureiro, Ana; Jennifer Noro; Abreu, Ana S.; Nogueira, E.; Soares da Costa, Diana; Silva, Carla; Cavaco-Paulo, Artur, The absence of albumin improves in vitro cellular uptake and disruption of Poloxamer 407-based nanoparticles inside cancer cells.
Abstract(s)Novel nanoparticles based on Poloxamer 407 and vegetable oil were produced by high pressure homogenization. Functionalization of those nanoparticles was made by incorporation of folic acid (FA)-Poloxamer 407 conjugate. These nanoparticles showed suitable characteristics for intravenous therapeutic applications similarly to PEGylated albumin-based nanoparticles, previously described by our research group. Here, we found that the absence of albumin at the interface of Poloxamer 407-based nanoparticles improves the overall process of in vitro cellular uptake and nanoparticles disruption inside cancer cells (folate receptor, FR, positive cells). The results present here suggests that interfacial composition of those nanoparticles is of paramount importance for drug trafficking inside cancer cells.
TypeArticle
URIhttp://hdl.handle.net/1822/51753
DOI10.1021/acs.molpharmaceut.7b00893
ISSN15438384
e-ISSN1543-8382
Publisher versionhttp://pubs.acs.org/journal/mpohbp
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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