Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/51426

TitleDevelopment of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids
Author(s)Salgado, Marta
Santos, Filipa
Rodríguez-Rojo, Soraya
Reis, R. L.
Duarte, Ana Rita C.
Cocero, María José
KeywordsAcetylsalicylic acid
Aerogel
Rheology
Supercritical drying
Supercritical impregnation
β-Glucan
beta-glucan
Issue date2-Nov-2017
PublisherElsevier
JournalJournal of Co2 Utilization
CitationSalgado M., Santos F., Rodríguez-Rojo S., Reis R. L., Duarte A. R. C., Cocero M. J. Development of barley and yeast β-glucan aerogels for drug delivery by supercritical fluids, Journal of CO₂ Utilization, Vol. 22, Issue -, pp. 262–269, doi:10.1016/j.jcou.2017.10.006, 2017
Abstract(s)Polysaccharide aerogels are a good alternative as carriers for drug delivery, since they allow high loading of the active compounds in matrices that are non-toxic, biocompatible and from a renewable feedstock. In this work, barley and yeast β-glucans aerogels were produced by gelation in aqueous solution, followed by solvent exchange and drying with supercritical CO2. First, viscoelastic properties and melting profile of the hydrogels were determined. Then, the obtained aerogels were analyzed regarding morphology, mechanical properties and behavior in physiological fluid. Both in the hydrogels and in the aerogels, big differences were observed between barley and yeast β-glucans due to their different chain structure and gelation behavior. Finally, impregnation of acetylsalicylic acid was performed at the same time as the drying of the alcogels with supercritical CO2. The release profile of the drug in PBS was analyzed in order to determine the mechanism governing the release from the β-glucan matrix.
TypeArticle
URIhttp://hdl.handle.net/1822/51426
DOI10.1016/j.jcou.2017.10.006
ISSN2212-9820
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S2212982017303190?via%3Dihub
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
19464-ARDuarte-JCO₂Utiliz2017.pdf2,51 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID