Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/51209
Título: | Microbubble moving in blood flow in microchannels: effect on the cell-free layer and cell local concentration |
Autor(es): | Bento, D. Sousa, Lúcia Yaginuma, T. Garcia, Valdemar Lima, Rui Alberto Madeira Macedo Miranda, João M. |
Palavras-chave: | Lab-On-A-Chip Devices Microbubbles Rheology Microfluidics Gas embolism Cell-free layer Red blood cells In vitro blood Micro bubble |
Data: | 2017 |
Editora: | Springer Verlag |
Revista: | Biomedical Microdevices |
Resumo(s): | Gas embolisms can hinder blood flow and lead to occlusion of the vessels and ischemia. Bubbles in microvessels circulate as tubular bubbles (Taylor bubbles) and can be trapped, blocking the normal flow of blood. To understand how Taylor bubbles flow in microcirculation, in particular, how bubbles disturb the blood flow at the scale of blood cells, experiments were performed in microchannels at a low Capillary number. Bubbles moving with a stream of in vitro blood were filmed with the help of a high-speed camera. Cell-free layers (CFLs) were observed downstream of the bubble, near the microchannel walls and along the centerline, and their thicknesses were quantified. Upstream to the bubble, the cell concentration is higher and CFLs are less clear. While just upstream of the bubble the maximum RBC concentration happens at positions closest to the wall, downstream the maximum is in an intermediate region between the centerline and the wall. Bubbles within microchannels promote complex spatio-temporal variations of the CFL thickness along the microchannel with significant relevance for local rheology and transport processes. The phenomenon is explained by the flow pattern characteristic of low Capillary number flows. Spatio-temporal variations of blood rheology may have an important role in bubble trapping and dislodging. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/51209 |
DOI: | 10.1007/s10544-016-0138-z |
ISSN: | 1387-2176 |
e-ISSN: | 1572-8781 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | DEM - Artigos em revistas de circulação internacional com arbitragem científica |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Bento_et_al_BM_2017s.pdf Acesso restrito! | 2,76 MB | Adobe PDF | Ver/Abrir |