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TitleAn efficient method for dehydration of 6-carbamoylpurines
Author(s)Fernandes, Mónica C. S.
Proença, M. Fernanda R. P.
Carvalho, M. Alice
Issue date2017
Abstract(s)6-cyanopurines of structure 1 (R’=H) were used in our research group to generate novel compounds with high activity against Mycobacterium tuberculosis [1,2]. The synthetic method to generate the cyanopurines 1 only allow a limited number of substituents on C2 of the nucleus [3,4,5]. In the research group there is an efficient synthetic method to generate 6- carbamoylpurines with multiple substituents on C2. The 6-carbamoylpurines will be used as precursors to generate 6-cyanopurines with the desired substituents on C2. In the literature, different methods are described for dehydration of amides [6,7,8,9,10]. In order to generate the target 6-cyanopurines 1, different reported methods were tested. When, ethyl dichlorophosphate was used the dehydration occurred and the products were obtained in good yield. All the results will be presented.
AccessRestricted access (Author)
Appears in Collections:CDQuim - Comunicações e Proceedings

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