Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50507
Título: | An efficient method for dehydration of 6-carbamoylpurines |
Autor(es): | Fernandes, Mónica C. S. Proença, M. Fernanda R. P. Carvalho, M. Alice |
Data: | 2017 |
Resumo(s): | 6-cyanopurines of structure 1 (R’=H) were used in our research group to generate novel compounds with high activity against Mycobacterium tuberculosis [1,2]. The synthetic method to generate the cyanopurines 1 only allow a limited number of substituents on C2 of the nucleus [3,4,5]. In the research group there is an efficient synthetic method to generate 6- carbamoylpurines with multiple substituents on C2. The 6-carbamoylpurines will be used as precursors to generate 6-cyanopurines with the desired substituents on C2. In the literature, different methods are described for dehydration of amides [6,7,8,9,10]. In order to generate the target 6-cyanopurines 1, different reported methods were tested. When, ethyl dichlorophosphate was used the dehydration occurred and the products were obtained in good yield. All the results will be presented. |
Tipo: | Poster em conferência |
URI: | https://hdl.handle.net/1822/50507 |
Arbitragem científica: | no |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2017_MF_IIISympMedChem_post.pdf Acesso restrito! | 38,39 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons