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https://hdl.handle.net/1822/50481
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Campo DC | Valor | Idioma |
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dc.contributor.author | Rocha, Ashly | por |
dc.contributor.author | Proença, M. Fernanda R. P. | por |
dc.contributor.author | Carvalho, M. Alice | por |
dc.date.accessioned | 2018-02-15T10:26:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://hdl.handle.net/1822/50481 | - |
dc.description.abstract | Cancer remains to be one of the leading causes of death worldwide of which the scientific community continuously struggles to combat on a daily basis [1]. In developed countries, colorectal cancer is one of the most frequent types of cancer where busy and stressful lifestyles contribute to diets rich in unhealthy fats which can be a preliminary cause of this cancer [2]. Unfortunately, there is not a concrete cure for this cancer and not all patients respond equally to the administered drugs [3]. Some even develop tumor resistance upon the intake of their therapeutic drugs due to the tumors’ different genetic profiles [3]. The ineffective treatment in many patients causes thousands of annual casualties which stimulated further research in prospect of novel anticancer drugs [1]. Recently, in our research group, the pyrimido[5,4-d]pyrimidines of general structure 1 (Figure 1) were identified as a new class of heterocyclic compounds active against HCT116 (p-53wt) colon cancer cells. The biological results showed that the activity depends on the substituents R and R1 that decorate the heterocycle. The synthetic strategy developed in our research group to generate the pyrimidopyrimidine ring has the 9-substitutedpurines as crucial intermediates [5, 6, 7], that are not available commercially. Herein, we describe the synthesis of new 9-substitutedpurine derivatives that will be used as starting reagents to synthesize new pyrimido[5,4-d]pyrimidines. | por |
dc.description.sponsorship | Thanks are due to University of Minho, Fundação para a Ciência e Tecnologia, Fundo Social Europeu, Programa Operacional Potencial Humano (POHP) of QREN for financial support of the PhD. grant SRFH/BD/85937/2012. | por |
dc.language.iso | eng | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F85937%2F2012/PT | por |
dc.rights | restrictedAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.title | Synthesis of new 9-(4´-RO-phenyl)-6-cyanopurine derivatives | por |
dc.type | conferenceAbstract | por |
dc.peerreviewed | no | por |
oaire.citationConferenceDate | 8 May 2015 | por |
sdum.event.title | 2nd Symposium on Medicinal Chemistry of University of Minho | por |
sdum.event.type | conference | por |
oaire.citationConferencePlace | Braga, Portugal | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2015_AT_2SympChemMed_post.pdf Acesso restrito! | 106,88 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons