Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/49425

TitleSynthesis of 2-(5’-phenylthien-2’-yl)benzothiazole
Author(s)Raposo, M. Manuela M.
Costa, Susana P. G.
Batista, Rosa Maria Ferreira
KeywordsChromatography
NMR
Benzothiazole
Intramolecular oxidative cyclization
Thiophene
Synthesis
Organic Chemistry Experiments
Laboratory Classroom
Issue date2016
PublisherRoyal Society of Chemistry
CitationRaposo, M. M. M.; Costa, S. P. G.: Batista, R. M. F. in Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), “Synthesis of 2-(5’-phenylthien-2’-yl)benzothiazole”, Afonso, C. A. M.; Franzén, R.; Tan, B.; Candeias, N. R.; Simão, D.; Trindade, A.; Coelho, J. (Eds); Royal Society of Chemistry 2016, Chapter 184, Experiment 12.2.1., p 832-835 (ISBN 978-18-49739-63-4).
Abstract(s)The aim of this work is the synthesis of a substituted heterocycle, namely a benzothiazole, using simple experimental techniques and commercially available reagents. The synthesis of this compound involves the synthesis of an imine by nucleophilic substitution of an amine with an aldehyde and intramolecular oxidative cyclization to the thiazole. Several experimental techniques will be considered such as thin layer chromatograpy (TLC), vacuum filtration, liquid-liquid extraction, and column chromatography on silica gel. The determination of the structure of the compound synthesized will be also performed through 1H NMR spectroscopy. The duration of the experiment will be 1 session for the preparation of 2-(5’-phenylthien-2’-yl)benzothiazole. The difficulty level of this experiment is low and the level of study is fundamental.
TypeBook part
DescriptionÉ um livro com 1000 experiências de trabalhos práticos que poderão ser usadas em aulas como componente prática de química orgânica para alunos universitários.
URIhttp://hdl.handle.net/1822/49425
ISBN978-18-49739-63-4
Publisher versionhttp://pubs.rsc.org/en/content/ebook/978-1-84973-963-4#!divbookcontent
AccessRestricted access (Author)
Appears in Collections:CDQuim - Livros e Capítulos de Livros / Books and Book Chapters

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