Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49290
Título: | Synthesis of N-tert-butyloxycarbonyl-[2-(thien-2’-yl)benzoxazol-5-yl]-l-alanine methyl ester |
Autor(es): | Costa, Susana P. G. Raposo, M. Manuela M. Esteves, Cátia Isabel Canavezes Ferreira, Rosa Cristina Moutinho |
Palavras-chave: | Amino acid (benz)oxazole Chromatography Nuclear magnetic resonance Oxidative cyclization Thiophene Organic chemistry experiments Laboratory classroom |
Data: | Dez-2016 |
Editora: | Royal Society of Chemistry |
Citação: | Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (COCELC), 2016, Cap. 185, Experiment 12.2.2, p 836-839. |
Resumo(s): | The aim of this work is the synthesis of a fluorescent heterocyclic amino acid, namely a benzoxazolyl- alanine, using simple experimental techniques and commercially available reagents. The starting aminotyrosine derivative and thiophene-2-carboxaldehyde will be combined in an oxidative cyclization to the oxazole in the presence of an oxidizing agent. The determination of the structure of the compound synthesized will be performed by 1H and 13C NMR spectroscopy. The experiment involves 3 sessions including the preparation of the intermediate N-tert-butyloxycarbonyl- 3-[(thien-2′-ylmethylene)amino]-l-tyrosine methyl ester and the preparation and purification of N-tert-butyloxycarbonyl[2-(thien-2′-yl)benzoxazol-5-yl]-l-alanine methyl ester. |
Tipo: | Capítulo de livro |
URI: | https://hdl.handle.net/1822/49290 |
ISBN: | 978-18-49739-63-4 |
Versão da editora: | http://pubs.rsc.org/en/content/ebook/978-1-84973-963-4 |
Acesso: | Acesso restrito autor |
Aparece nas coleções: | CDQuim - Livros e Capítulos de Livros / Books and Book Chapters |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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BO-alanina repositorium.pdf Acesso restrito! | 1,14 MB | Adobe PDF | Ver/Abrir |