Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/48442

TitleThe carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate
Author(s)Alves, R.
Mota, Sandra
Silva, Sónia Carina
Rodrigues, Célia F.
Brown, Alistair J.
Henriques, Mariana
Casal, Margarida
Paiva, Sandra
KeywordsCandida
Candida albicans
Fluconazole
Carboxylic acid transporters
Jen1 Jen2
Biofilm
Matrix
Resistance
alternative carbon sources
antifungal drug resistance
biofilm formation
lactate
Issue date2-Nov-2017
PublisherTaylor & Francis
JournalBiofouling: The Journal of Bioadhesion and Biofilm Research
CitationAlves, R.; Mota, Sandra; Silva, Sónia Carina; Rodrigues, Célia F.; Brown, Alistair J.; Henriques, Mariana; Casal, Margarida; Paiva, Sandra, The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate. Biofouling - The Journal of Bioadhesion and Biofilm Research, 33(10), 943-954, 2017
Abstract(s)Candida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process. The results show that growth on lactate affects biofilm formation, morphology and susceptibility to fluconazole and that both Jen1 and Jen2 might play a role in these processes. These results support the view that the adaptation of Candida cells to the carbon source present in the host niches affects their pathogenicity.
TypeArticle
URIhttp://hdl.handle.net/1822/48442
DOI10.1080/08927014.2017.1392514
ISSN08927014
e-ISSN1029-2454
Publisher versionhttp://www.tandfonline.com/action/journalInformation?journalCode=gbif20
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
DBio - Artigos/Papers

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