Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/48150

TítuloBioinspiring Chondrosia reniformis (Nardo, 1847) collagen-based hydrogel: a new extraction method to obtain a sticky and self-healing collagenous material
Autor(es)Fassini, Dario
Duarte, Ana Rita C.
Reis, R. L.
Silva, Tiago José Quinteiros Lopes Henriques
Palavras-chaveChondrosia reniformis
Collagen rheology
Hydrogel
Marine biomaterials
Marine collagen
Marine sponge GAG
DataDez-2017
EditoraMultidisciplinary Digital Publishing Institute (MDPI)
RevistaMarine Drugs
CitaçãoFassini D., Duarte A. R. C., Reis R. L., Silva T. H. Bioinspiring Chondrosia reniformis (Nardo, 1847) Collagen-Based Hydrogel: A New Extraction Method to Obtain a Sticky and Self-Healing Collagenous Material, Marine Drugs, Vol. 15, Issue 12, pp. 380-397, doi:10.3390/md15120380, 2017
Resumo(s)Collagen is a natural and abundant polymer that serves multiple functions in both invertebrates and vertebrates. As collagen is the natural scaffolding for cells, collagen-based hydrogels are regarded as ideal materials for tissue engineering applications since they can mimic the natural cellular microenvironment. Chondrosia reniformis is a marine demosponge particularly rich in collagen, characterized by the presence of labile interfibrillar crosslinks similarly to those described in the mutable collagenous tissues (MCTs) of echinoderms. As a result single fibrils can be isolated using calcium-chelating and disulphide-reducing chemicals. In the present work we firstly describe a new extraction method that directly produces a highly hydrated hydrogel with interesting self-healing properties. The materials obtained were then biochemically and rheologically characterized. Our investigation has shown that the developed extraction procedure is able to extract collagen as well as other proteins and Glycosaminoglycans (GAG)-like molecules that give the collagenous hydrogel interesting and new rheological properties when compared to other described collagenous materials. The present work motivates further in-depth investigations towards the development of a new class of injectable collagenous hydrogels with tailored specifications.
Tipoarticle
URIhttp://hdl.handle.net/1822/48150
DOI10.3390/md15120380
ISSN1660-3397
Versão da editorahttp://www.mdpi.com/1660-3397/15/12/380
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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