Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/46997

TitleBioplotting of a bioactive alginate dialdehyde-gelatin composite hydrogel containing bioactive glass nanoparticles
Author(s)Leite, Álvaro J.
Sarker, Bapi
Zehnder, Tobias
Silva, Raquel
Mano, J. F.
Boccaccini, A. R.
KeywordsAlginate
Bioactive glass Nanoparticles
Bioactivity
Biofabrication
Bioplotting
Composite
Gelatin
Issue dateJul-2016
PublisherIOP Publishing
JournalBiofabrication
CitationLeite A. J., Sarker B., Zehnder T., Silva R., Mano J. F., Boccaccini A. R. Bioplotting of a bioactive alginate dialdehyde-gelatin composite hydrogel containing bioactive glass nanoparticles., Biofabrication, Vol. 8, Issue 3, pp. 035005-8, doi:10.1088/1758-5090/8/3/035005, 2016
Abstract(s)Alginate dialdehyde-gelatin (ADA-GEL) constructs incorporating bioactive glass nanoparticles (BGNPs) were produced by biofabrication to obtain a grid-like highly-hydrated composite. The material could induce the deposition of an apatite layer upon immersion in a biological-like environment to sustain cell attachment and proliferation. Composites were formulated with different concentrations of BGNPs synthetized from a sol-gel route, namely 0.1% and 0.5% (w/v). Strontium doped BGNPs were also used. EDS analysis suggested that the BGNPs loading promoted the growth of bone-like apatite layer on the surface when the constructs were immersed in a simulated body fluid. Moreover, the composite constructs could incorporate with high efficiency ibuprofen as a drug model. Furthermore, the biofabrication process allowed the successful incorporation of MG-63 cells into the composite material. Cells were distributed homogeneously within the hydrogel composite, and no differences were found in cell viability between ADA-GEL and the composite constructs, proving that the addition of BGNPs did not influence cell fate. Overall, the composite material showed potential for future applications in bone tissue engineering.
TypeArticle
URIhttp://hdl.handle.net/1822/46997
DOI10.1088/1758-5090/8/3/035005
ISSN1758-5090
Publisher versionhttp://iopscience.iop.org/article/10.1088/1758-5090/8/3/035005/meta
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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