Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46997
Título: | Bioplotting of a bioactive alginate dialdehyde-gelatin composite hydrogel containing bioactive glass nanoparticles |
Autor(es): | Leite, Álvaro J. Sarker, Bapi Zehnder, Tobias Silva, Raquel Mano, J. F. Boccaccini, A. R. |
Palavras-chave: | Alginate Bioactive glass Nanoparticles Bioactivity Biofabrication Bioplotting Composite Gelatin |
Data: | Jul-2016 |
Editora: | IOP Publishing |
Revista: | Biofabrication |
Citação: | Leite A. J., Sarker B., Zehnder T., Silva R., Mano J. F., Boccaccini A. R. Bioplotting of a bioactive alginate dialdehyde-gelatin composite hydrogel containing bioactive glass nanoparticles., Biofabrication, Vol. 8, Issue 3, pp. 035005-8, doi:10.1088/1758-5090/8/3/035005, 2016 |
Resumo(s): | Alginate dialdehyde-gelatin (ADA-GEL) constructs incorporating bioactive glass nanoparticles (BGNPs) were produced by biofabrication to obtain a grid-like highly-hydrated composite. The material could induce the deposition of an apatite layer upon immersion in a biological-like environment to sustain cell attachment and proliferation. Composites were formulated with different concentrations of BGNPs synthetized from a sol-gel route, namely 0.1% and 0.5% (w/v). Strontium doped BGNPs were also used. EDS analysis suggested that the BGNPs loading promoted the growth of bone-like apatite layer on the surface when the constructs were immersed in a simulated body fluid. Moreover, the composite constructs could incorporate with high efficiency ibuprofen as a drug model. Furthermore, the biofabrication process allowed the successful incorporation of MG-63 cells into the composite material. Cells were distributed homogeneously within the hydrogel composite, and no differences were found in cell viability between ADA-GEL and the composite constructs, proving that the addition of BGNPs did not influence cell fate. Overall, the composite material showed potential for future applications in bone tissue engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/46997 |
DOI: | 10.1088/1758-5090/8/3/035005 |
ISSN: | 1758-5090 |
Versão da editora: | http://iopscience.iop.org/article/10.1088/1758-5090/8/3/035005/meta |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19118-ALeite-Biofabrication2016.pdf Acesso restrito! | 3,05 MB | Adobe PDF | Ver/Abrir |