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|Title:||3D segmentation of intervertebral discs: from concept to the fabrication of patient-specific scaffolds|
Cengiz, I. F.
Oliveira, J. M.
Reis, R. L.
|Journal:||Journal of 3D Printing in Medicine|
|Citation:||Oner T., Cengiz I. F., Pitikakis M., Cesario L., Parascandolo P., Vosilla L., Viano G., Oliveira J. M., Reis R. L., Silva-Correia J. 3D segmentation of intervertebral discs: From concept to the fabrication of patient-specific scaffolds, Journal of 3D Printing in Medicine, Vol. 1, Issue 2, pp. 91-101, doi:10.2217/3dp-2016-0011, 2017|
|Abstract(s):||Aim: To develop a methodology for producing patient-specific scaffolds that mimic the annulus fibrosus (AF) of the human intervertebral disc (IVD) by means of combining magnetic resonance imaging (MRI) and 3D bioprinting. Methods: In order to obtain the AF 3D model from patientâ s volumetric MRI dataset, the RheumaSCORE segmentation software was used. Polycaprolactone scaffolds with three different internal architectures were fabricated by 3D bioprinting, and characterized by micro-computed tomography. Results: The demonstrated methodology of a geometry reconstruction pipeline enabled to successfully obtain an accurate AF model and 3D print patient-specific scaffolds with different internal architectures. Conclusion: The results guide us towards patient-specific IVD tissue engineering as demonstrated a way of manufacturing personalized scaffolds using patient's MRI data.|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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