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TitleImpact of polymicrobial biofilms in catheter-associated urinary tract infections
Author(s)Azevedo, Andreia S.
Almeida, Carina
Melo, Luís F.
Azevedo, Nuno F.
KeywordsCatheter-associated urinary tract infections
Pathogenic bacteria
Uncommon bacteria
Microbial ecology
Issue date2017
PublisherTaylor and Francis
JournalCritical Reviews in Microbiology
CitationAzevedo, Andreia S.; Almeida, Carina; Melo, Luís F.; Azevedo, Nuno F., Impact of polymicrobial biofilms in catheter-associated urinary tract infections. Critical Reviews in Microbiology, 43(4), 423-439, 2017
Abstract(s)Recent reports have demonstrated that most biofilms involved in catheter-associated urinary tract infections are polymicrobial communities, with pathogenic microorganisms (e.g. Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and uncommon microorganisms (e.g. Delftia tsuruhatensis, Achromobacter xylosoxidans) frequently co-inhabiting the same urinary catheter. However, little is known about the interactions that occur between different microorganisms and how they impact biofilm formation and infection outcome. This lack of knowledge affects CAUTIs management as uncommon bacteria action can, for instance, influence the rate at which pathogens adhere and grow, as well as affect the overall biofilm resistance to antibiotics. Another relevant aspect is the understanding of factors that drive a single pathogenic bacterium to become prevalent in a polymicrobial community and subsequently cause infection. In this review, a general overview about the IMDs-associated biofilm infections is provided, with an emphasis on the pathophysiology and the microbiome composition of CAUTIs. Based on the available literature, it is clear that more research about the microbiome interaction, mechanisms of biofilm formation and of antimicrobial tolerance of the polymicrobial consortium are required to better understand and treat these infections.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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