Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/44844

TitleCandida species biofilms' antifungal resistance
Author(s)Silva, Sónia Carina
Rodrigues, Célia Fortuna
Araújo, Daniela
Rodrigues, Maria Elisa Costa
Henriques, Mariana
KeywordsCandidiasis
Biofilm
Resistance
Mechanisms
Issue date21-Feb-2017
PublisherMDPI
JournalJournal of Fungi
CitationSilva, Sónia Carina; Rodrigues, Célia F.; Araújo, Daniela; Rodrigues, M. Elisa; Henriques, Mariana, Candida species biofilms' antifungal resistance. Journal of Fungi, 3(1, 8), 1-17, 2017
Abstract(s)Candida infections (candidiasis) are the most prevalent opportunistic fungal infection on humans and, as such, a major public health problem. In recent decades, candidiasis has been associated to Candida species other than Candida albicans. Moreover, biofilms have been considered the most prevalent growth form of Candida cells and a strong causative agent of the intensification of antifungal resistance. As yet, no specific resistance factor has been identified as the sole responsible for the increased recalcitrance to antifungal agents exhibited by biofilms. Instead, biofilm antifungal resistance is a complex multifactorial phenomenon, which still remains to be fully elucidated and understood. The different mechanisms, which may be responsible for the intrinsic resistance of Candida species biofilms, include the high density of cells within the biofilm, the growth and nutrient limitation, the effects of the biofilm matrix, the presence of persister cells, the antifungal resistance gene expression and the increase of sterols on the membrane of biofilm cells. Thus, this review intends to provide information on the recent advances about Candida species biofilm antifungal resistance and its implication on intensification of the candidiasis.
TypeArticle
URIhttp://hdl.handle.net/1822/44844
DOI10.3390/jof3010008
e-ISSN2309-608X
Publisher versionhttp://www.mdpi.com/journal/jof
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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