Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/44828

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dc.contributor.authorPérez-Pérez, Martínpor
dc.contributor.authorJorge, Paulapor
dc.contributor.authorRodríguez, Gael Pérezpor
dc.contributor.authorPereira, Maria Olíviapor
dc.contributor.authorLourenço, Análiapor
dc.date.accessioned2017-02-21T15:27:03Z-
dc.date.available2017-02-21T15:27:03Z-
dc.date.issued2017-01-25-
dc.identifier.citationPérez-Pérez, Martín; Jorge, Paula; Rodríguez, Gael Pérez; Pereira, Maria Olívia; Lourenço, Anália, Quorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network mining. Biofouling, 33(2), 128-142, 2017por
dc.identifier.issn0892-7014por
dc.identifier.urihttp://hdl.handle.net/1822/44828-
dc.description.abstractQuorum sensing plays a pivotal role in Pseudomonas aeruginosas virulence. This paper reviews experimental results on antimicrobial strategies based on quorum sensing inhibition and discusses current targets in the regulatory network that determines P. aeruginosa biofilm formation and virulence. A bioinformatics framework combining literature mining with information from biomedical ontologies and curated databases was used to create a knowledge network of potential anti-quorum sensing agents for P. aeruginosa. A total of 110 scientific articles, corresponding to 1,004 annotations were so far included in the network and are analysed in this work. Information on the most studied agents, QS targets and methods is detailed. This knowledge network offers a unique view of existing strategies for quorum sensing inhibition and their main regulatory targets and may be used to readily access otherwise scattered information and to help generate new testable hypotheses. This knowledge network is publicly available at http://pcquorum.org/por
dc.description.sponsorshipThis work was partially funded by the Research Grant 2014 of Anália Lourenço by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), the INOU16-05 project from the Provincial Council of Ourense, the European Union’s Seventh Framework Programme FP7/ REGPOT-2012-2013.1 [grant agreement number 316265], BIOCAPS, the Portuguese Foundation for Science and Technology (FCT) under the strategic funding of UID/BIO/04469/2013 unit, the FCT and the European Community fund FEDER, through Programme COMPETE, under the scope of the Project RECI/BBB- EBI/0179/2012 [FCOMP-010124-FEDER-027462]. SING group also thanks CITI (Centro de Investigación, Transferencia e Innovación) from University of Vigo for hosting its IT infrastructure. The authors also acknowledge FCT for the PhD Grant to Paula Jorge [grant number SFRH/BD/88192/2012]. M. Pérez-Pérez and G. Pérez Rodríguez were supported by pre-doctoral fellowships from the Xunta de Galicia and the University of Vigo.por
dc.language.isoengpor
dc.publisherTaylor & Francispor
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/316265/EUpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147337/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/126270/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/COMPETE/126270/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F88192%2F2012/PTpor
dc.rightsopenAccesspor
dc.subjectQuorum-sensingpor
dc.subjectQuorum-quenchingpor
dc.subjectPseudomonas aeruginosapor
dc.subjectBiofilmpor
dc.subjectBioinformaticspor
dc.subjectNetworkspor
dc.titleQuorum sensing inhibition in Pseudomonas aeruginosa biofilms: new insights through network miningpor
dc.typearticle-
dc.peerreviewedyespor
dc.commentsCEB46556por
sdum.publicationstatusinfo:eu-repo/semantics/publishedVersionpor
oaire.citationStartPage128por
oaire.citationEndPage142por
oaire.citationIssue2por
oaire.citationTitleBiofoulingpor
oaire.citationVolume33por
dc.date.updated2017-02-21T09:00:12Z-
dc.identifier.essn1029-2454por
dc.identifier.doi10.1080/08927014.2016.1272104por
dc.identifier.pmid28121162por
dc.subject.wosScience & Technologypor
sdum.journalBiofoulingpor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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