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https://hdl.handle.net/1822/44411
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Campo DC | Valor | Idioma |
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dc.contributor.author | Sánchez, Borja | por |
dc.contributor.author | Delgado, Susana | por |
dc.contributor.author | Blanco-Míguez, Aitor | por |
dc.contributor.author | Lourenço, Anália | por |
dc.contributor.author | Gueimonde, Miguel | por |
dc.contributor.author | Margolles, Abelardo | por |
dc.date.accessioned | 2017-01-19T16:59:39Z | - |
dc.date.available | 2017-01-19T16:59:39Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Sánchez, Borja; Delgado, Susana; Blanco-Míguez, Aitor; Lourenço, Anália; Gueimonde, Miguel; Margolles, Abelardo, Probiotics, gut microbiota and their influence on host health and disease. Molecular Nutrition and Food Research, 61(1), 1600240, 2017 | por |
dc.identifier.issn | 1613-4125 | por |
dc.identifier.uri | https://hdl.handle.net/1822/44411 | - |
dc.description.abstract | The gastrointestinal tract (GIT) of mammals hosts a high and diverse number of different microorganisms, known as intestinal microbiota. Many probiotics were originally isolated from the GIT, and they were defined by the FAO/WHO as live microorganisms which when administered in adequate amounts confer a health benefit on the host. Probiotics exert their beneficial effects on the host through four main mechanisms: interference with potential pathogens, improvement of barrier function, immunomodulation and production of neurotransmitters, and their host targets vary from the resident microbiota to cellular components of the gut-brain axis. However, in spite of the wide array of beneficial mechanisms deployed by probiotic bacteria, relatively few effects have been supported by clinical data. In this regard, different probiotic strains have been effective in Antibiotic-Associated Diarrhea or Inflammatory Bowel Disease for instance. The aim of this review was to compile the molecular mechanisms underlying the beneficial effects of probiotics, mainly through their interaction with the intestinal microbiota and with the intestinal mucosa. The specific benefits discuss in this paper include among others those elicited directly through dietary modulation of the human gut microbiota.This article is protected by copyright. All rights reserved | por |
dc.description.sponsorship | Research in our lab is funded by Grants AGL2013-44039R and AGL2013-44761-P from the Spanish “Plan Estatal de I+D+I.” Part of the authors is also partially funded by the [15VI013] Contract-Programme from the University of Vigo and the Agrupamento INBIOMED from DXPCTSUG-FEDER unha maneira de facer Europa (2012/273). B. S. was recipient of a Ramón y Cajal postdoctoral contract from the Spanish Ministry of Economy and Competitiveness. | por |
dc.language.iso | eng | por |
dc.publisher | John Wiley and Sons | por |
dc.rights | openAccess | por |
dc.subject | Gut microbiota | por |
dc.subject | Health effects | por |
dc.subject | Molecular mechanisms | por |
dc.subject | bioinformatics | por |
dc.subject | Probiotics | por |
dc.subject | Molecular mechanisms bioinformatics | por |
dc.title | Probiotics, gut microbiota and their influence on host health and disease | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-4133 | por |
dc.comments | CEB40144 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 1600240 | por |
oaire.citationIssue | 1 | por |
oaire.citationConferencePlace | United Kingdom | - |
oaire.citationTitle | Molecular Nutrition and Food Research | por |
oaire.citationVolume | 61 | por |
dc.date.updated | 2017-01-14T19:51:33Z | - |
dc.identifier.doi | 10.1002/mnfr.201600240 | por |
dc.identifier.pmid | 27500859 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Molecular Nutrition and Food Research | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_40144_1.pdf | 553,3 kB | Adobe PDF | Ver/Abrir |