Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/44382

TítuloThe key role of sulfation and branching on fucoidan antitumor activity
Autor(es)Oliveira, Catarina
Ferreira, Andreia S.
Novoa Carballal, R.
Nunes, Cláudia
Pashkuleva, I.
Neves, N. M.
Coimbra, Manuel A.
Reis, R. L.
Martins, Albino
Silva, Tiago José Quinteiros Lopes Henriques
Palavras-chaveAntitumor activity
Fucoidan
Polymer branching
Structure–activity relationship
Sulfation
Data2017
EditoraJohn Wiley and Sons
RevistaMacromolecular Bioscience
CitaçãoOliveira C., Ferreira A. S., Novoa-Carballal R., Nunes C., Pashkuleva I., Neves N. M., Coimbra M. A., Reis R. L., Martins A., Silva T. H. The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity, Macromolecular Bioscience, doi:10.1002/mabi.201600340, 2016
Resumo(s)There is an urgent need for antitumor bioactive agents with minimal or no side effects over normal adjacent cells. Fucoidan is a marine-origin polymer with known antitumor activity. However, there are still some concerns about its application due to the inconsistent experimental results, specifically its toxicity over normal cells and the mechanism behind its action. Herein, three fucoidan extracts (FEs) have been tested over normal and breast cancer cell lines. From cytotoxicity results, only one of the extracts shows selective antitumor behavior (at 0.2 mg mLâ 1), despite similarities in sulfation degree and carbohydrates composition. Although the three FEs present different molecular weights, depolymerization of selected samples discarded Mw as the key factor in the antitumor activity. Significant differences in sulfates position and branching are observed, presenting FE 2 the higher branching degree. Based on all these experimental data, it is believed that these last two properties are the ones that influence the cytotoxic effects of fucoidan extracts.
Tipoarticle
URIhttp://hdl.handle.net/1822/44382
DOI10.1002/mabi.201600340
ISSN1616-5195
Versão da editorahttp://dx.doi.org/10.1002/mabi.201600340
Arbitragem científicano
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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