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TitleWetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration
Author(s)Fernandes, J. S.
Reis, R. L.
Pires, R. A.
Borosilicate bioactive glasses
Interconnected porosity
Poly-L-lactic acid
Issue date2017
JournalMaterials Science and Engineering: C
CitationFernandes J. S., Reis R. L., Pires R. A. Wetspun poly-L-(lactic acid)-borosilicate bioactive glass scaffolds for guided bone regeneration, Materials Science and Engineering: C, doi:10.1016/j.msec.2016.10.007, 2017.
Abstract(s)We developed a porous poly-L-lactic acid (PLLA) scaffold compounded with borosilicate bioactive glasses (BBGs) endowing it with bioactive properties. Porous PLLA-BBG fibre mesh scaffolds were successfully prepared by the combination of wet spinning and fibre bonding techniques. Micro-computed tomography (μCT) confirmed that the PLLA-BBG scaffolds containing ≈ 25% of BBGs (w/w) exhibited randomly interconnected porous (58 to 62% of interconnectivity and 53 to 67% of porosity) with mean pore diameters higher that 100 μm. Bioactivity and degradation studies were performed by immersing the scaffolds in simulated body fluid (SBF) and ultrapure water, respectively. The PLLA-BBG scaffolds presented a faster degradation rate with a constant release of inorganic species, which are capable to produce calcium phosphate structures at the surface of the material after 7 days of immersion in SBF (Ca/P ratio of ~ 1.7). Cellular in vitro studies with human osteosarcoma cell line (Saos-2) and human adipose-derived stem cells (hASCs) showed that PLLA-BBGs are not cytotoxic to cells, while demonstrating their capacity to promote cell adhesion and proliferation. Overall, we showed that the proposed scaffolds present a tailored kinetics on the release of inorganic species and controlled biological response under conditions that mimic the bone physiological environment.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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