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TitleGenetically Engineered Phages: a Review of Advances over the Last Decade
Author(s)Pires, Diana P.
Cleto, Sara
Sillankorva, Sanna
Azeredo, Joana
Lu, Timothy K.
Issue dateSep-2016
PublisherAmerican Society for Microbiology (ASM)
JournalMicrobiology and Molecular Biology Reviews
CitationPires, Diana P.; Cleto, Sara; Sillankorva, Sanna; Azeredo, Joana; Lu, Timothy K., Genetically Engineered Phages: a Review of Advances over the Last Decade. Microbiology and Molecular Biology Reviews, 80(3), 523-543, 2016
Abstract(s)Summary: Soon after their discovery in the early 20th century, bacteriophages were recognized to have great potential as antimicrobial agents, a potential that has yet to be fully realized. The nascent field of phage therapy was adversely affected by inadequately controlled trials and the discovery of antibiotics. Although the study of phages as anti-infective agents slowed, phages played an important role in the development of molecular biology. In recent years, the increase in multidrug-resistant bacteria has renewed interest in the use of phages as antimicrobial agents. With the wide array of possibilities offered by genetic engineering, these bacterial viruses are being modified to precisely control and detect bacteria and to serve as new sources of antibacterials. In applications that go beyond their antimicrobial activity, phages are also being developed as vehicles for drug delivery and vaccines, as well as for the assembly of new materials. This review highlights advances in techniques used to engineer phages for all of these purposes and discusses existing challenges and opportunities for future work.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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