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https://hdl.handle.net/1822/43245
Título: | Combinatorial approaches with selected phytochemicals to increase antibiotic efficacy against Staphylococcus aureus biofilms |
Autor(es): | Abreu, Ana Cristina Saavedra, Maria José Simões, Lúcia C. Simões, Manuel |
Palavras-chave: | Antibiotic adaptation antibiotic resistance biofilms efflux pump phytochemicals Staphylococcus aureus |
Data: | 2016 |
Editora: | Taylor and Francis |
Revista: | Biofouling |
Citação: | Abreu, Ana Cristina; Saavedra, Maria José; Simões, Lúcia C.; Simões, Manuel, Combinatorial approaches with selected phytochemicals to increase antibiotic efficacy against Staphylococcus aureus biofilms. Biofouling: The Journal of Bioadhesion and Biofilm Research, 32(9), 1103-1114, 2016 |
Resumo(s): | Combinations of selected phytochemicals (reserpine, pyrrolidine, quinine, morin and quercetin) with antibiotics (ciprofloxacin, tetracycline and erythromycin) were tested on the prevention and control of Staphylococcus aureus biofilms. The phytochemicals were also studied for their ability to avoid antibiotic adaptation and to inhibit antibiotic efflux pumps. Morin, pyrrolidine and quercetin at subinhibitory concentrations had significant effects in biofilm prevention and/or control when applied alone and combined with antibiotics. Synergism between antibiotics and phytochemicals was found especially against biofilms of NorA overexpressing strain S. aureus SA1199B. This strain when growing with subinhibitory concentrations of ciprofloxacin developed increased tolerance to this antibiotic. However, this was successfully reversed by quinine and morin. In addition, reserpine and quercetin showed significant efflux pump inhibition. The overall results demonstrate the role of phytochemicals in co-therapies to promote more efficient treatments and decrease antimicrobial resistance to antibiotics, with substantial effects against S. aureus in both planktonic and biofilm states. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/43245 |
DOI: | 10.1080/08927014.2016.1232402 |
ISSN: | 0892-7014 |
e-ISSN: | 1029-2454 |
Versão da editora: | http://www.tandfonline.com/action/journalInformation?journalCode=gbif20 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46225_1.pdf | 1,6 MB | Adobe PDF | Ver/Abrir |