Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/42503

TitleFunctionalised collagen-MnO2 fibres inhibit oxidative-induced apoptosis in degenerated IVD
Author(s)Pereira, Diana Ribeiro
Tapeinos, C.
Oliveira, J. M.
Reis, R. L.
Pandit, A.
KeywordsCollagen
IL1b
IVD
Manganese dioxide
Nanoparticles
ROS
Scavenging effect
Issue dateJul-2016
PublisherAO Foundation
CitationPereira D. R., Tapeinos C., Oliveira J. M., Reis R. L., Pandit A. Functionalised collagen-MnO2 fibres inhibit oxidative-induced apoptosis in degenerated IVD, European Cells & Materials, Vol. 31, Issue 1, pp. P50, 14732262, 2016
Abstract(s)Intervertebral disc cell apoptosis has been reported as the major factor responsible in promoting disc degeneration. In this study we hypothesize that collagen fibres with manganese dioxide (MnO2) nanoparticles (NPs) can increase oxygen levels by scavenging ROS species and converting it into byproducts. The specific objective of this study is to fabricate collagen fibres incorporating NPs (Fig. 1), with controlled degradability that are able to scavenge ROS species and generate O2 while inhibiting annulus fibrosus (AF) cell apoptosis under inflamed conditions.
TypeAbstract
URIhttp://hdl.handle.net/1822/42503
ISSN14732262
Publisher versionhttp://www.ecmjournal.org/journal/supplements/vol031supp01/vol031supp01_P.htm
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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