Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/42496

TítuloRecent progress on gellan gum hydrogels provided by functionalization strategies
AutorBacelar, Ana Helena Dias
Silva-Correia, Joana
Oliveira, J. M.
Reis, R. L.
Palavras-chaveBlending
Chemical modification
Gellan gum
Hydrogels
Regenerative medicine
Tissue engineering
DataAgo-2016
EditoraRoyal Society of Chemistry
CitaçãoBacelar A. H., Silva-Correia J., Oliveira J. M., Reis R. L. Recent progress on gellan gum hydrogels provided by functionalization strategies, Journal of Materials Chemistry B, doi:10.1039/C6TB01488G, 2016
ResumoGellan gum, a microbial exopolysaccharide fermentation product of Pseudomonas elodea, is a natural biomaterial that has shown promise for tissue engineering and regenerative medicine applications. Although this exopolysaccharide possesses many advantages, such interesting physicochemical properties and non-cytotoxicity, the mechanical properties and processability of gellan gum are not totally satisfactory in different tissue engineering contexts, i.e. gellan gum hydrogels are mechanically weak and the high gelling temperature is also unfavourable. An additional critical limitation is the lack of specific attachment sites for anchorage-dependent cells. However, the multiple hydroxyl groups and the free carboxyl per repeating unit of gellan gum can be used for chemical modification and functionalization in order to optimize its physicochemical and biological properties. A number of physical modification approaches have also been employed. This review outlines the recent progresses for gellan gum hydrogels and derivatives, and identifies the new challenges in tissue engineering, provided by blending and/or chemical modifications.
Tipoarticle
URIhttp://hdl.handle.net/1822/42496
DOI10.1039/C6TB01488G
ISSN2050-7518
Versão da editorahttp://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01488G#!divAbstract
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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