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TitleBioengineered strategies for tendon regeneration
Author(s)Gonçalves, Ana Isabel Silva
Rodrigues, Márcia T.
Reis, R. L.
Gomes, Manuela E.
KeywordsBiomaterials mechanical stimulation
Tendon substitutes
Tendon tissue engineering strategies
Tenogenic differentiation
Mechanical stimulation
Issue dateAug-2016
PublisherAcademic Press
CitationGonçalves A. I., Rodrigues M. T., Reis R. L., Gomes M. E. Bioengineered Strategies for Tendon Regeneration, In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design, pp. 275-294, doi:10.1016/B978-0-12-802225-2.00015-5, 2016
Abstract(s)Their important mechanical function predisposes tendons to injury and rupture, becoming a worldwide clinical problem. Commonly injured tendons include the rotator cuff, finger flexors, patellar, and Achilles tendon [1]. As poor cellular and vascular tissues [2], tendons present some healing constraints, typically requiring surgical intervention. Available reparative surgeries rely on tissue replacement with auto- or allografts [3], which are often accompanied with donor site morbidity, pain, inferior functionalities, and eventually graft failure. Due to the market demand, commercial substitutes for tendon repair have been developed as biological and synthetic scaffolds.
TypeBook part
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Capítulos de Livros/Book Chapters

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