Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/42261

TitleCandida glabrata’s recurrent infections: biofilm formation during Amphotericin B treatment
Author(s)Rodrigues, Célia Fortuna
Silva, Sónia Carina
Azeredo, Joana
Henriques, Mariana
KeywordsAmphotericin B
Biofilm cells
Biofilms
Candida glabrata
Matrix composition
Issue date2016
PublisherBlackwell Publishing
JournalLetters in Applied Microbiology
CitationRodrigues, Célia F.; Silva, Sónia Carina; Azeredo, Joana; Henriques, Mariana, Candida glabrata's recurrent infections: biofilms formation during Amphotericin B treatment. Letters in Applied Microbiology, 63(2), 77-81, 2016
Abstract(s)Candida species are responsible for recurrent human infections, mostly in immunocompromised patients, due to their high vulnerability. Candida glabrata has a major role in systemic candidiasis and Amphotericin B (AmB), a hospital environment exclusive polyene, is frequently used to treat this disease. Lately, however, clinical evidences of Candida recurrent infections during these treatments are being described, probably due to biofilms (re)formation during this therapy. Thus, this work aims at inferring if C. glabrata biofilms are still being formed during AmB treatment. For that, C. glabrata biofilms were formed in the presence of AmB and analysed by dry weight. Matrix composition was analysed quantifying carbohydrates and, specifically, -1,3 glucans. Results demonstrated that, although in a lesser extent, C. glabrata is able to develop biofilms in the presence of AmB, with a thick extracellular matrix, with an increase on carbohydrates, especially -1,3 glucans. Therefore, it is confirmed that complex biofilms of C. glabrata can be formed during an AmB treatment.
TypeArticle
URIhttp://hdl.handle.net/1822/42261
DOI10.1111/lam.12600
ISSN0266-8254
e-ISSN1472-765X
Publisher versionhttp://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1472-765X
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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