Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/40254

Full metadata record
DC FieldValueLanguage
dc.contributor.authorMagalhães, Andreiapor
dc.contributor.authorAzevedo, Nuno F.por
dc.contributor.authorPereira, Maria Olíviapor
dc.contributor.authorLopes, Susana Patríciapor
dc.date.accessioned2016-02-12T15:37:11Z-
dc.date.available2016-02-12T15:37:11Z-
dc.date.issued2016-02-
dc.date.submitted2015-08-
dc.identifier.citationMagalhães, A. P., Azevedo, N. F., Pereira, M. O., & Lopes, S. P. (2016). The cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapy. Applied microbiology and biotechnology, 100(3), 1163-1181por
dc.identifier.issn0175-7598por
dc.identifier.urihttp://hdl.handle.net/1822/40254-
dc.description.abstractThe recent focus on the cystic fibrosis (CF) complex microbiome has led to the recognition that the microbes can interact between them and with the host immune system, affecting the disease progression and treatment routes. Although the main focus remains on the interactions between traditional pathogens, growing evidence supports the contribution and the role of emergent species. Understanding the mechanisms and the biological effects involved in polymicrobial interactions may be the key to improve effective therapies and also to define new strategies for disease control. This review focuses on the interactions between microbe-microbe and host-microbe, from an ecological point of view, discussing their impact on CF disease progression. There are increasing indications that these interactions impact the success of antimicrobial therapy. Consequently, a new approach where therapy is personalized to patients by taking into account their individual CF microbiome is suggested.por
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT), the strategic funding of UID/BIO/04469/2013-CEB and UID/EQU/00511/2013-LEPABE units. This study was also supported by FCT and the European Community fund FEDER, through Program COMPETE, under the scope of the Projects “DNA mimics” PIC/IC/82815/2007, RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462), “BioHealth—Biotechnology and Bioengineering approaches to improve health quality”, Ref. NORTE-07-0124-FEDER-000027 and NORTE-07-0124-FEDER-000025—RL2_ Environment and Health, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER. The authors also acknowledge the grant of Susana P. Lopes (SFRH/BPD/95616/2013) and of the COST-Action TD1004: Theragnostics for imaging and therapy.por
dc.language.isoengpor
dc.publisherSpringer por
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147337/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147284/PTpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/126270/PTpor
dc.rightsopenAccesspor
dc.subjectCystic fibrosispor
dc.subjectEcological perspectivepor
dc.subjectMicrobe-microbe interactionspor
dc.subjectMicrobe-host interactionspor
dc.subjectPolymicrobial biofilmspor
dc.subjectAntibiotic therapypor
dc.titleThe cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapypor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://link.springer.com/article/10.1007/s00253-015-7177-xpor
dc.commentsCEB26573por
sdum.publicationstatuspublishedpor
oaire.citationStartPage1163por
oaire.citationEndPage1181por
oaire.citationIssue3por
oaire.citationConferencePlaceGermany-
oaire.citationTitleApplied Microbiology and Biotechnologypor
oaire.citationVolume100por
dc.date.updated2016-01-24T16:08:43Z-
dc.identifier.essn1432-0614-
dc.identifier.doi10.1007/s00253-015-7177-xpor
dc.identifier.pmid26637419por
dc.subject.fosCiências Médicas::Medicina Clínicapor
dc.subject.wosScience & Technologypor
sdum.journalApplied Microbiology and Biotechnologypor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
document_26573_1.pdf2,08 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID