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TitleBiomimetic supramolecular designs for the controlled release of growth factors in bone regeneration
Author(s)Azevedo, Helena S.
Pashkuleva, I.
Extracellular matrix
Growth factors
Molecular recognition
Multivalent interactions
Issue dateAug-2015
PublisherElsevier Science BV
JournalAdvanced Drug Delivery Reviews
CitationPashkuleva I., Azevedo H. S. Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration, Advanced Drug Delivery Reviews, Vol. 94, pp. 63-76, doi:10.1016/j.addr.2015.08.003, 2015
Abstract(s)The extracellular matrix (ECM) of tissues is an assembly of insoluble macromolecules that specifically interact with soluble bioactive molecules and regulate their distribution and availability to cells. Recapitulating this ability has been an important target in controlled growth factor delivery strategies for tissue regeneration and requires the design of multifunctional carriers. This review describes the integration of supramolecular interactions on the design of delivery strategies that encompass self-assembling and engineered affinity components to construct advanced biomimetic carriers for growth factor delivery. Several glycan- and peptide-based self-assemblies reported in the literature are highlighted and commented upon. These examples demonstrate how molecular design and chemistry are successfully employed to create versatile multifunctional molecules which self-assemble/disassemble in a precisely predicted manner, thus controlling compartmentalization, transport and delivery. Finally, we discuss whether recent advances in the design and preparation of supramolecular delivery systems have been sufficient to drive real translation towards a clinical impact. 
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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