Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/39115
Título: | A novel and efficient approach to new N3-substituted-6,8-diaminopurines |
Autor(es): | Senhorães, Nádia Proença, M. Fernanda R. P. Dias, Alice |
Palavras-chave: | Química Orgânica |
Data: | 1-Dez-2015 |
Resumo(s): | [Excerpt] Purine nucleobases are fundamental biochemicals in living organisms. They have been a valuable inspiration for drug design once they play several key roles in the cell.1 To the best of our knowledge, reported routes to 8-aminopurines are still scarce due to the difficulty in introducing amino groups in this position of the purine ring. Here we report a novel, inexpensive and facile synthetic method to generate N3,N6-disubstituted-6,8-diaminopurines. In our research group, a number of substituted purines have been obtained from a common imidazole precursor, the 5-amino-4-cyanoformimidoyl imidazole 1. Recently, a comprehensive study on the reactivity of imidazoles 1 with nucleophiles under acidic conditions led us to develop experimental methods to incorporate primary amines into the cyanoformimidoyl group.2 (...) |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/39115 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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SQM_A novel and efficient approach to new N3-substituted-6,8-diaminopurines.pdf Acesso restrito! | 111,31 kB | Adobe PDF | Ver/Abrir |