Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/39113
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Fernandes, Soraia P. | por |
dc.contributor.author | Proença, M. Fernanda R. P. | por |
dc.contributor.author | Wilson, Cristina Pereira | por |
dc.contributor.author | Dias, Alice | por |
dc.date.accessioned | 2015-12-21T18:57:27Z | - |
dc.date.issued | 2015-05-08 | - |
dc.identifier.uri | https://hdl.handle.net/1822/39113 | - |
dc.description.abstract | [Excerpt] Purines, such as adenine, are one of the most important naturally occurring nitrogen heterocycles and they are frequently used as bioactive agents.[1,2] The increasing number of synthetic purines reveals the great potential of these compounds as enzyme inhibitors. Protein Kinases have an important regulatory role in cell proliferation, differentiation and signalling processes. Abnormal signal transduction is responsible for devastating diseases such as cancer. All of the protein kinases identified have in common the cofactor ATP indicating that the adenine nucleus is a very important scaffold for discovery of new anti-cancer agents.[3,4] Previous work identified a modest anticancer activity in a family of 6-arylaminopurines. In the view of these results, it seemed reasonable to assume that some interesting anticancer agents might result by replacement of the phenyl group by a secondary amino group linked to the N-6 atom of the adenine moiety. (...) | por |
dc.description.sponsorship | FCT (NMR portuguese network); FCT and FEDER-COMPETE-QREN-EU [Pest-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)] | por |
dc.language.iso | eng | por |
dc.relation | Pest-C/QUI/UI0686/2011 | por |
dc.rights | restrictedAccess | por |
dc.subject | Química Orgânica | por |
dc.subject | Biologia | por |
dc.title | The synthesis of new 6-hydrazinopurines as potential anticancer agents | por |
dc.type | conferenceAbstract | - |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationConferenceDate | 8 Maio 2015 | por |
sdum.event.type | congress | por |
oaire.citationTitle | 2nd Symposium on Medicinal Chemistry of the University of Minho | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.fos | Ciências Naturais::Ciências Biológicas | por |
sdum.conferencePublication | 2nd Symposium on Medicinal Chemistry of the University of Minho | por |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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SQM_The Synthesis of New 6-Hydrazinopurines as Potential Anti-cancer Agents - Soraia Fernandes.pdf Acesso restrito! | 96,22 kB | Adobe PDF | Ver/Abrir |