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TitleA new and efficient synthesis of benzoimidazopurine derivatives
Author(s)Senhorães, Nádia
Proença, M. Fernanda R. P.
Dias, Alice
KeywordsQuímica Orgânica
Issue date8-May-2015
Abstract(s)[Excerpt] Purine nucleobases are essential biomolecules in living organisms. Playing several key roles in the cell, they have been a significant inspiration for drug design.1 Benzimidazole nucleus is an important pharmacophore in the development of molecules with pharmaceutical or biological interest. Benzimidazoles have been reported to display significant pharmacological activities such as antiulcer, antifungal, antiparkinson, anticancer and antibiotic.2 Fused structures incorporating these two scaffolds might be important for medicinal chemistry and, to the best of our knowledge, there are no reports of these systems in the literature. In particular, benzo[4,5]imidazo[2,1]purines seem to be novel and must be important target molecules in the heterocyclic synthesis. (...)
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Comunicações e Proceedings

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